DrugDashboards

Midazolam

Midazolam Hydrochloride · MIDAZOLAM HYDROCHLORIDE 5 mg/mL · Injection, Solution · Intramuscular; Intravenous · Hospira, Inc.

NDC 00409-2596-05 · 10 VIAL, MULTI-DOSE in 1 CARTON / 10 mL in 1 VIAL, MULTI-DOSE · ANDA · View full market →

The short version

14 companies supply this market — deep enough that no single failure threatens the supply. The price is down 15% over the past year, to $0.3817 per mL. It is in shortage right now — FDA lists the reason as “demand increase for the drug”. Put together: worth watching — several of the pressures that precede supply trouble are present at once.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$0.3817per MLinvoice-surveyed acquisition cost · Aug 19, 2026
  • Medicare Part B pays (ASP+6%)$0.1430per billing unit (1 MG)HCPCS J2250 · Jul 1, 2026

Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

$0$0.25$0.5$0.75Jan 2014Sep 2026$0.3817
13 price points · per MLSource: CMS NADAC

Estimated fill cost

WAC per package, as filed
$75.17
Reported to Texas DSHS · 2026 annual filing · Pfizer Inc.

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicare Part B (ASP)

Payment limit per 1 MG
$0.143
HCPCS J2250 · Jul 1, 2026 quarter · typically ASP + 6%

Medicaid spend (2025)

$9,025
650 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

35● Elevated risk

The score is counting real pressure here. One of these alone is routine; it’s the combination that makes this market worth watching.

  • in shortage now+25
  • sterile injectable+10

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.4%chance of a new FDA shortage posting for midazolam hydrochloride (injectable) in the next 90 days

sterile injectable · sole-source market · price up 3% YoY

For scale: the typical drug’s chance is about 0.1% — this one is 3× that.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

  • Hospira, Inc.United States
    analysis · label · manufacture · pack
  • Hospira, Inc.United States
    analysis · label · manufacture · pack

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

  • Part D specialty tier
  • Costs ≥ $950/fill
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program

Regulatory

Application
ANDA075293
TE code
AP
Approval date
Jun 20, 2000
Patents / exclusivity
None on file

Shortage history

  • In shortage now — Midazolam Hydrochloride Preservative Free, Injection, 10 mg/2 mL (5 mg/mL) (NDC 0409-2308-02)Apr 2, 2020
    Demand increase for the drug
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride Preservative Free, Injection, 2 mg/2 mL (NDC 76045-211-20)Apr 2, 2020
    Demand increase for the drug
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride Preservative Free, Injection, 2 mg/2mL (1 mg/mL) (NDC 0409-2305-17)Apr 2, 2020
    Demand increase for the drug
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride Preservative Free, Injection, 5 mg/5 mL (1 mg/mL) (NDC 0409-2305-05)Apr 2, 2020
    Demand increase for the drug
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride Preservative Free, Injection, 5 mg/mL (5 mg/mL) (NDC 0409-2308-01)Apr 2, 2020
    Demand increase for the drug
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride, Injection, 1 mg/1 mL (NDC 23155-600-41)Apr 2, 2020
    Demand increase for the drug
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride, Injection, 1 mg/1 mL (NDC 25021-655-02)Apr 2, 2020
    Other
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride, Injection, 1 mg/1 mL (NDC 63323-411-10)Apr 2, 2020
    Delay in shipping of the drug
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride, Injection, 1 mg/1 mL (NDC 63323-411-12)Apr 2, 2020
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride, Injection, 1 mg/1 mL (NDC 63323-411-25)Apr 2, 2020
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride, Injection, 10 mg/10 mL (1 mg/mL) (NDC 0409-2587-05)Apr 2, 2020
    Demand increase for the drug
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride, Injection, 25 mg/5 mL (5 mg/mL) (NDC 0409-2596-03)Apr 2, 2020
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride, Injection, 5 mg/1 mL (NDC 23155-601-41)Apr 2, 2020
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride, Injection, 5 mg/1 mL (NDC 23155-601-42)Apr 2, 2020
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride, Injection, 5 mg/1 mL (NDC 25021-661-10)Apr 2, 2020
    Other
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride, Injection, 5 mg/1 mL (NDC 63323-412-02)Apr 2, 2020
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride, Injection, 5 mg/1 mL (NDC 63323-412-10)Apr 2, 2020
    Demand increase for the drug
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride, Injection, 5 mg/1 mL (NDC 63323-412-25)Apr 2, 2020
    Demand increase for the drug
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months
  • In shortage now — Midazolam Hydrochloride, Injection, 50 mg/10 mL (5 mg/mL) (NDC 0409-2596-05)Apr 2, 2020
    month 78 — 4× the typical 20-month injectable shortage · model puts 25% odds it resolves within 6 months

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Midazolam Hydrochloride (Injection, Solution)

LabelerStrengthFirst seenLast seen
Onesource Specialty Pharma LimitedMIDAZOLAM HYDROCHLORIDE 5 mg/mLJul 15, 2026Sep 3, 2026
A-S Medication SolutionsMIDAZOLAM HYDROCHLORIDE 1 mg/mLJul 15, 2026Sep 2, 2026
A-S Medication SolutionsMIDAZOLAM HYDROCHLORIDE 5 mg/mLJul 15, 2026Sep 2, 2026
Belcher Pharmaceuticals, LLCMIDAZOLAM HYDROCHLORIDE 5 mg/mLJul 15, 2026Sep 2, 2026
Cardinal Health 107, LLCMIDAZOLAM HYDROCHLORIDE 1 mg/mLJul 15, 2026Sep 2, 2026
Fresenius Kabi USA, LLCMIDAZOLAM HYDROCHLORIDE 1 mg/mLJul 15, 2026Sep 2, 2026
Gland Pharma LimitedMIDAZOLAM HYDROCHLORIDE 5 mg/mLJul 15, 2026Sep 2, 2026
Gland Pharma LimitedMIDAZOLAM HYDROCHLORIDE 1 mg/mLJul 15, 2026Sep 2, 2026
Henry Schein, Inc.MIDAZOLAM HYDROCHLORIDE 5 mg/mLJul 15, 2026Sep 2, 2026
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.MIDAZOLAM HYDROCHLORIDE 5 mg/mLJul 15, 2026Sep 2, 2026
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.MIDAZOLAM HYDROCHLORIDE 1 mg/mLJul 15, 2026Sep 2, 2026
Jvet Pharmaceuticals LLCMIDAZOLAM HYDROCHLORIDE 5 mg/mLJul 15, 2026Sep 2, 2026
Remedyrepack Inc.MIDAZOLAM HYDROCHLORIDE 2 mg/2mLJul 15, 2026Sep 2, 2026
Sagent PharmaceuticalsMIDAZOLAM HYDROCHLORIDE 5 mg/mLJul 15, 2026Sep 2, 2026
Somerset Therapeutics, LlcMIDAZOLAM HYDROCHLORIDE 5 mg/5mLJul 15, 2026Sep 2, 2026
Somerset Therapeutics, LlcMIDAZOLAM HYDROCHLORIDE 2 mg/2mLJul 15, 2026Sep 2, 2026
Somerset Therapeutics, LlcMIDAZOLAM HYDROCHLORIDE 5 mg/mLJul 15, 2026Sep 2, 2026
Steriscience Specialties Private LimitedMIDAZOLAM HYDROCHLORIDE 5 mg/mLJul 15, 2026Sep 2, 2026
Steriscience Specialties Private LimitedMIDAZOLAM HYDROCHLORIDE 1 mg/mLJul 15, 2026Sep 2, 2026
Onesource Specialty Pharma LimitedMIDAZOLAM HYDROCHLORIDE 1 mg/mLJul 15, 2026Aug 31, 2026
Sagent PharmaceuticalsMIDAZOLAM HYDROCHLORIDE 1 mg/mLJul 15, 2026Aug 31, 2026
Fresenius Kabi USA, LLCMIDAZOLAM HYDROCHLORIDE 2 mg/2mLJul 15, 2026Aug 29, 2026
Fresenius Kabi USA, LLCMIDAZOLAM HYDROCHLORIDE 5 mg/mLJul 15, 2026Aug 28, 2026
Hospira, Inc.MIDAZOLAM HYDROCHLORIDE 5 mg/mLJul 15, 2026Aug 28, 2026
Hospira, Inc.MIDAZOLAM HYDROCHLORIDE 1 mg/mLJul 15, 2026Aug 28, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Midazolam — NDC 00409-2596-05," retrieved September 3, 2026, https://drugdashboards.com/drug/00409259605.

Free to cite with attribution — see how the data is put together.