DrugDashboards

Naltrexone Hydrochloride

Naltrexone Hydrochloride · NALTREXONE HYDROCHLORIDE 50 mg/1 · Tablet, Film Coated · Oral · Accord Healthcare, Inc.

NDC 16729-0081-10 · 30 TABLET, FILM COATED in 1 BOTTLE · ANDA · View full market →

The short version

21 companies supply this market — deep enough that no single failure threatens the supply. The price is down 8% over the past year, to $1.14 per unit. A shortage here was resolved within the past year — markets usually stay tight for a while after. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$1.14per EAinvoice-surveyed acquisition cost · Aug 19, 2026
  • Part D point of sale (median)$1.39per unitnegotiated price across 5,510 plans — before rebates · Jan 1, 2026
  • Medicaid generic ceiling (FUL)$1.14per TABweighted avg manufacturer price $0.6520 · Aug 1, 2026100% of what pharmacies pay — higher than 57% of drugs with this benchmark

Medicare Part D

All Part D pricing →
ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$1.39per unit
middle half $0.7595$2.13 · 5,510 plans · Jan 1, 2026
Est. net of rebates
≈ $1.39
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
100%of plans cover it
tier 2 · prior auth 0% · step therapy 0% · qty limit 0%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 4 quarters since 2024.

NADAC price per unit

$0$0.5$1.00$1.50Nov 2013Sep 2026$1.14
155 price points · per EA · dashed = manufacturer avg (WAMP)Source: CMS NADAC

Estimated fill cost

#30 count
$34.18
#90 count
$102.53

Estimates: latest NADAC unit price × quantity. Pharmacy acquisition cost only — excludes dispensing fees, markup, and insurance terms.

Medicaid spend (2025)

$2.5M
64,942 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

8Low risk

Some pressure is visible, but not much — here’s everything the score found to count.

  • shortage resolved within 12 months+8

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.2%chance of a new FDA shortage posting for naltrexone hydrochloride (oral solid) in the next 90 days

OAI inspection at a producing facility (24 months) · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Regulatory

Application
ANDA091205
TE code
AB
Approval date
Aug 17, 2011
Patents / exclusivity
None on file

Shortage history

  • Shortage ended Naltrexone Hydrochloride, Tablet, 50 mg (NDC 0406-1170-01)Feb 29, 2024 → Feb 11, 2026
  • Shortage ended Naltrexone Hydrochloride, Tablet, 50 mg (NDC 0406-1170-03)Feb 29, 2024 → Feb 11, 2026
  • Shortage ended Naltrexone Hydrochloride, Tablet, 50 mg (NDC 16729-081-01)Feb 29, 2024 → Feb 11, 2026
  • Shortage ended Naltrexone Hydrochloride, Tablet, 50 mg (NDC 16729-081-10)Feb 29, 2024 → Feb 11, 2026
  • Shortage ended Naltrexone Hydrochloride, Tablet, 50 mg (NDC 47335-326-08)Feb 29, 2024 → Feb 11, 2026
  • Shortage ended Naltrexone Hydrochloride, Tablet, 50 mg (NDC 47335-326-18)Feb 29, 2024 → Feb 11, 2026
  • Shortage ended Naltrexone Hydrochloride, Tablet, 50 mg (NDC 47335-326-83)Feb 29, 2024 → Feb 11, 2026
  • Shortage ended Naltrexone Hydrochloride, Tablet, 50 mg (NDC 47335-326-88)Feb 29, 2024 → Feb 11, 2026
  • Shortage ended Naltrexone Hydrochloride, Tablet, 50 mg (NDC 51224-206-30)Feb 29, 2024 → Feb 11, 2026
  • Shortage ended Naltrexone Hydrochloride, Tablet, 50 mg (NDC 51224-206-50)Feb 29, 2024 → Feb 11, 2026
  • Shortage ended Naltrexone Hydrochloride, Tablet, 50 mg (NDC 62135-242-60)Feb 29, 2024 → Feb 11, 2026
  • Shortage ended Naltrexone Hydrochloride, Tablet, 50 mg (NDC 64850-300-01)Feb 29, 2024 → Feb 11, 2026
  • Shortage ended Naltrexone Hydrochloride, Tablet, 50 mg (NDC 64850-300-30)Feb 29, 2024 → Feb 11, 2026
  • Shortage ended Naltrexone Hydrochloride, Tablet, 50 mg (NDC 68094-909-30)Feb 29, 2024 → Feb 11, 2026
  • Shortage ended Naltrexone Hydrochloride, Tablet, 50 mg (NDC 68094-909-50)Feb 29, 2024 → Feb 11, 2026

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Naltrexone Hydrochloride (Tablet, Film Coated)

LabelerStrengthFirst seenLast seen
Aphena Pharma Solutions - Tennessee, LLCNALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 3, 2026
Bryant Ranch PrepackNALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 3, 2026
Coupler LLCNALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 3, 2026
Remedyrepack Inc.NALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 3, 2026
Accord Healthcare, Inc.NALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
American Health PackagingNALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
AvKARENALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Chartwell RX, LLCNALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Elite Laboratories, Inc.NALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Golden State Medical Supply, Inc.NALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Heritage Pharmaceuticals Inc d/b/a Avet Pharmaceuticals IncNALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Major PharmaceuticalsNALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
NCS HealthCare of KY, LLC dba Vangard LabsNALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
NuCare Pharmaceuticals Inc.NALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Proficient Rx LPNALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
SpecGx LLCNALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Sun Pharmaceutical Industries, Inc.NALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
TAGI Pharma Inc.NALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
A-S Medication SolutionsNALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Aug 31, 2026
Redpharm DrugNALTREXONE HYDROCHLORIDE 50 mg/1Jul 25, 2026Aug 29, 2026
Precision Dose Inc.NALTREXONE HYDROCHLORIDE 50 mg/1Jul 15, 2026Aug 28, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Naltrexone Hydrochloride — NDC 16729-0081-10," retrieved September 3, 2026, https://drugdashboards.com/drug/16729008110.

Free to cite with attribution — see how the data is put together.