Methotrexate · METHOTREXATE 25 mg/mL · Injection · Intra-Arterial; Intramuscular; Intrathecal; Intravenous · Accord Healthcare, Inc.
NDC 16729-0277-30 · 1 VIAL in 1 CARTON / 2 mL in 1 VIAL · ANDA · View full market →
Only one company currently supplies this market — there is no backup if it stumbles. The price is down 26% over the past year, to $1.76 per mL. It is in shortage right now — FDA lists the reason as “other”. Put together: this is a fragile supply — if anything else goes wrong, there is very little slack to absorb it.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.
Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.
How Part D pricing works →Manufacturer list price as filed — not what pharmacies actually pay after discounts.
Several kinds of pressure are visible at once — each line below is a condition that historically precedes supply trouble, and this market is stacking them.
The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026
sterile injectable · sole-source market · price up 1% YoY
For scale: the typical drug’s chance is about 0.1% — this one is 3× that.
Backtested statistical model over the whole market, not this package alone. Model details →
Establishments this product's FDA label declares, located via FDA registration data. How we built this →
There's no legal definition — it meets 2 of 6 public criteria. Why that matters →
No enforcement reports list this package NDC.
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Accord Healthcare, Inc. | METHOTREXATE 25 mg/mL | Jul 15, 2026 | Sep 2, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
DrugDashboards, "Methotrexate — NDC 16729-0277-30," retrieved September 3, 2026, https://drugdashboards.com/drug/16729027730.
Free to cite with attribution — see how the data is put together.