DrugDashboards

Bupropion Hydrochloride

Bupropion Hydrochloride · BUPROPION HYDROCHLORIDE 300 mg/1 · Tablet, Extended Release · Oral · Accord Healthcare Inc.

NDC 16729-0444-16 · 500 TABLET, EXTENDED RELEASE in 1 BOTTLE · ANDA · View full market →

The short version

20 companies supply this market — deep enough that no single failure threatens the supply. The price has fallen 32% in a year, to $0.1014 per unit — and generics that get this cheap tend to get abandoned rather than defended. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$0.1014per EAinvoice-surveyed acquisition cost · Aug 19, 2026
  • Medicaid generic ceiling (FUL)$0.1964per TABweighted avg manufacturer price $0.1122 · Aug 1, 2026194% of what pharmacies pay — higher than 86% of drugs with this benchmark

Medicare Part D

All Part D pricing →

Matched to CMS's representative package for this drug (NDC 70436-0011-02) — same generic, strength, and dosage form. CMS prices one NDC per drug concept, not every package.

ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$0.3957per unit
middle half $0.2085$0.4632 · 5,496 plans · Apr 1, 2026
Est. net of rebates
≈ $0.3957
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
100%of plans cover it
tier 2 · prior auth 0% · step therapy 0% · qty limit 72%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.

NADAC price per unit

$0$0.2$0.4$0.6Apr 2019Sep 2026$0.1014
90 price points · per EA · dashed = manufacturer avg (WAMP)Source: CMS NADAC

Estimated fill cost

#30 count
$3.04
#90 count
$9.12

Estimates: latest NADAC unit price × quantity. Pharmacy acquisition cost only — excludes dispensing fees, markup, and insurance terms.

Medicaid spend (2025)

$475,479
36,250 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

16Low risk

Some pressure is visible, but not much — here’s everything the score found to count.

  • Class I/II recall on same molecule/form in past 12 months+8
  • price down 32% year over year+8

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for bupropion hydrochloride (oral solid) in the next 90 days

OAI inspection at a producing facility (24 months) · sole-source market · 1 Class I/II recall(s) in 12 months

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Regulatory

Application
ANDA210497
TE code
AB3
Approval date
Oct 31, 2018
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Bupropion Hydrochloride (Tablet, Extended Release)

LabelerStrengthFirst seenLast seen
A-S Medication SolutionsBUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 3, 2026
A-S Medication SolutionsBUPROPION HYDROCHLORIDE 300 mg/1Jul 15, 2026Sep 3, 2026
Bryant Ranch PrepackBUPROPION HYDROCHLORIDE 200 mg/1Jul 15, 2026Sep 3, 2026
Bryant Ranch PrepackBUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 3, 2026
Bryant Ranch PrepackBUPROPION HYDROCHLORIDE 100 mg/1Jul 15, 2026Sep 3, 2026
Camber Pharmaceuticals, Inc.BUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 3, 2026
Coupler LLCBUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 3, 2026
Epic Pharma, LLCBUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 3, 2026
Epic Pharma, LLCBUPROPION HYDROCHLORIDE 300 mg/1Jul 15, 2026Sep 3, 2026
Preferred Pharmaceuticals Inc.BUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 3, 2026
Preferred Pharmaceuticals Inc.BUPROPION HYDROCHLORIDE 300 mg/1Jul 15, 2026Sep 3, 2026
Proficient Rx LPBUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 3, 2026
Proficient Rx LPBUPROPION HYDROCHLORIDE 300 mg/1Jul 15, 2026Sep 3, 2026
Remedyrepack Inc.BUPROPION HYDROCHLORIDE 300 mg/1Jul 15, 2026Sep 3, 2026
Slate Run Pharmaceuticals, LLCBUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 3, 2026
A-S Medication SolutionsBUPROPION HYDROCHLORIDE 100 mg/1Jul 15, 2026Sep 2, 2026
Accord Healthcare Inc.BUPROPION HYDROCHLORIDE 300 mg/1Jul 15, 2026Sep 2, 2026
Accord Healthcare Inc.BUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 2, 2026
Actavis Pharma, Inc.BUPROPION HYDROCHLORIDE 300 mg/1Jul 15, 2026Sep 2, 2026
Advanced Rx of Tennessee, LLCBUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 2, 2026
Advanced Rx of Tennessee, LLCBUPROPION HYDROCHLORIDE 300 mg/1Jul 15, 2026Sep 2, 2026
Advanced Rx Pharmacy of Tennessee, LLCBUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 2, 2026
American Health PackagingBUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 2, 2026
American Health PackagingBUPROPION HYDROCHLORIDE 300 mg/1Jul 15, 2026Sep 2, 2026
Asclemed USA, Inc.BUPROPION HYDROCHLORIDE 300 mg/1Jul 15, 2026Sep 2, 2026
AvPAKBUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 2, 2026
AvPAKBUPROPION HYDROCHLORIDE 300 mg/1Jul 15, 2026Sep 2, 2026
Bausch Health US LLCBUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 2, 2026
Bausch Health US LLCBUPROPION HYDROCHLORIDE 300 mg/1Jul 15, 2026Sep 2, 2026
BluePoint LaboratoriesBUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 2, 2026
BluePoint LaboratoriesBUPROPION HYDROCHLORIDE 300 mg/1Jul 15, 2026Sep 2, 2026
Camber Pharmaceuticals, Inc.BUPROPION HYDROCHLORIDE 300 mg/1Jul 15, 2026Sep 2, 2026
Camber Pharmaceuticals, Inc.BUPROPION HYDROCHLORIDE 100 mg/1Jul 15, 2026Sep 2, 2026
Camber Pharmaceuticals, Inc.BUPROPION HYDROCHLORIDE 200 mg/1Jul 15, 2026Sep 2, 2026
Cipla USA Inc.,BUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 2, 2026
Cipla USA Inc.,BUPROPION HYDROCHLORIDE 200 mg/1Jul 15, 2026Sep 2, 2026
Cipla USA Inc.,BUPROPION HYDROCHLORIDE 100 mg/1Jul 15, 2026Sep 2, 2026
Cipla Usa Inc.,BUPROPION HYDROCHLORIDE 300 mg/1Jul 15, 2026Sep 2, 2026
Cipla Usa Inc.,BUPROPION HYDROCHLORIDE 150 mg/1Jul 15, 2026Sep 2, 2026
Coupler LLCBUPROPION HYDROCHLORIDE 100 mg/1Jul 15, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Bupropion Hydrochloride — NDC 16729-0444-16," retrieved September 3, 2026, https://drugdashboards.com/drug/16729044416.

Free to cite with attribution — see how the data is put together.