DrugDashboards

Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release

Hydrocodone Polistirex and Chlorpheniramine Polistirex · HYDROCODONE BITARTRATE 10 mg/5mL; CHLORPHENIRAMINE MALEATE 8 mg/5mL · Suspension, Extended Release · Oral · Cranbury Pharmaceuticals, LLC

NDC 27808-0086-02 · 473 mL in 1 BOTTLE · ANDA · View full market →

The short version

Just 2 companies supply this market — thin enough that a single exit would be felt immediately. The price has jumped 80% in a year, to $0.6503 per mL — sharp rises like this often mean supply is already tightening. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$0.6503per MLinvoice-surveyed acquisition cost · Aug 19, 2026
  • List price (WAC, as filed)$456.00per packageCranbury Pharmaceuticals, LLC · Oct 1, 2025

Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

$0$0.25$0.5$0.75Oct 2015Sep 2026$0.6503
127 price points · per MLSource: CMS NADAC

Estimated fill cost

WAC per package, as filed
$456.00
Reported to Texas DSHS · 2026 annual filing · Cranbury Pharmaceuticals, LLC

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicaid spend (2025)

$56,512
1,161 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

20Low risk

Some pressure is visible, but not much — here’s everything the score found to count.

  • 2 active manufacturers+20

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.2%chance of a new FDA shortage posting for hydrocodone polistirex and chlorpheniramine polistirex (other) in the next 90 days

price up 30% YoY · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

  • Part D specialty tier
  • Costs ≥ $950/fill
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program · Opioid Analgesic REMS Shared System REMS

Regulatory

Application
ANDA091632
TE code
Approval date
Oct 1, 2010
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

  • Class II · TerminatedJul 11, 2019
    Tris Pharma Inc.Superpotent Drug and Failed Stability Specifications: High out-of-specification results for the active ingredients, hydrocodone and chlorpheniramine, as well as high out-of-specification results for the preservatives.

Manufacturers of Hydrocodone Polistirex and Chlorpheniramine Polistirex (Suspension, Extended Release)

LabelerStrengthFirst seenLast seen
Bryant Ranch PrepackHYDROCODONE BITARTRATE 10 mg/5mL; CHLORPHENIRAMINE MALEATE 8 mg/5mLAug 26, 2026Sep 3, 2026
Cranbury Pharmaceuticals, LLCHYDROCODONE BITARTRATE 10 mg/5mL; CHLORPHENIRAMINE MALEATE 8 mg/5mLAug 26, 2026Sep 2, 2026
Bryant Ranch PrepackHYDROCODONE BITARTRATE 8 mg/5mL; CHLORPHENIRAMINE MALEATE 10 mg/5mLJul 22, 2026Aug 22, 2026
Cranbury Pharmaceuticals, LLCHYDROCODONE BITARTRATE 8 mg/5mL; CHLORPHENIRAMINE MALEATE 10 mg/5mLJul 22, 2026Aug 19, 2026
Bryant Ranch PrepackCHLORPHENIRAMINE MALEATE 8 mg/5mL; HYDROCODONE BITARTRATE 10 mg/5mLJul 15, 2026Jul 18, 2026
Cranbury Pharmaceuticals, LLCCHLORPHENIRAMINE MALEATE 8 mg/5mL; HYDROCODONE BITARTRATE 10 mg/5mLJul 15, 2026Jul 15, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release — NDC 27808-0086-02," retrieved September 3, 2026, https://drugdashboards.com/drug/27808008602.

Free to cite with attribution — see how the data is put together.