Dextromethorphan HBr, Phenylephrine HCl, Pyrilamine Maleate · DEXTROMETHORPHAN HYDROBROMIDE 7.5 mg/5mL; PYRILAMINE MALEATE 12.5 mg/5mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/5mL · Syrup · Oral · Poly Pharmaceuticals, Inc.
NDC 50991-0132-16 · 480 mL in 1 BOTTLE · OTC MONOGRAPH DRUG · View full market →
Only one company currently supplies this market — there is no backup if it stumbles. The price is down 10% over the past year, to $0.0623 per mL. Put together: worth watching — several of the pressures that precede supply trouble are present at once.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Medicare Part D does not cover over-the-counter drugs — by law it pays only for products requiring a prescription.
How Part D pricing works →The score is counting real pressure here. One of these alone is routine; it’s the combination that makes this market worth watching.
The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
No FDA shortage reports for this drug or its presentations.
No enforcement reports list this package NDC.
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Poly Pharmaceuticals, Inc. | DEXTROMETHORPHAN HYDROBROMIDE 7.5 mg/5mL; PYRILAMINE MALEATE 12.5 mg/5mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/5mL | Aug 26, 2026 | Sep 2, 2026 |
| Poly Pharmaceuticals, Inc. | DEXTROMETHORPHAN HYDROBROMIDE 7.5 mg/5mL; PYRILAMINE MALEATE 5 mg/5mL; PHENYLEPHRINE HYDROCHLORIDE 12.5 mg/5mL | Jul 22, 2026 | Aug 19, 2026 |
| Poly Pharmaceuticals, Inc. | DEXTROMETHORPHAN HYDROBROMIDE 7.5 mg/5mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/5mL; PYRILAMINE MALEATE 12.5 mg/5mL | Jul 15, 2026 | Jul 15, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
DrugDashboards, "Polytussin DM — NDC 50991-0132-16," retrieved September 3, 2026, https://drugdashboards.com/drug/50991013216.
Free to cite with attribution — see how the data is put together.