DrugDashboards

Acetaminophen and Codeine Phosphate

Acetaminophen and Codeine Phosphate · ACETAMINOPHEN 120 mg/5mL; CODEINE PHOSPHATE 12 mg/5mL · Solution · Oral · Genus Lifesciences Inc.

NDC 64950-0374-16 · 473 mL in 1 BOTTLE, PLASTIC · ANDA · View full market →

The short version

Just 2 companies supply this market — thin enough that a single exit would be felt immediately. The price has held steady around $0.4692 per mL over the past year. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$0.4692per MLinvoice-surveyed acquisition cost · Aug 19, 2026
  • Part D point of sale (median)$0.4512per unitnegotiated price across 5,401 plans — before rebates · Apr 1, 2026

Medicare Part D

All Part D pricing →
ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$0.4512per unit
middle half $0.3584$0.5535 · 5,401 plans · Apr 1, 2026
Est. net of rebates
≈ $0.4512
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
98%of plans cover it
tier 3 · prior auth 2% · step therapy 0% · qty limit 95%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.

NADAC price per unit

$0$0.2$0.4$0.6Dec 2023Sep 2026$0.4692
31 price points · per MLSource: CMS NADAC

Medicaid spend (2025)

$160,775
2,377 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

20Low risk

Some pressure is visible, but not much — here’s everything the score found to count.

  • 2 active manufacturers+20

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for acetaminophen and codeine phosphate (other) in the next 90 days

sole-source market · price up 4% YoY

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

  • Part D specialty tier · median tier 3 across plans
  • Costs ≥ $950/fill
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program · Opioid Analgesic REMS Shared System REMS

Regulatory

Application
ANDA087508
TE code
Approval date
Jan 1, 1982
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Acetaminophen and Codeine Phosphate (Solution)

LabelerStrengthFirst seenLast seen
PAI Holdings, LLC dba PAI PharmaACETAMINOPHEN 120 mg/5mL; CODEINE PHOSPHATE 12 mg/5mLAug 13, 2026Sep 3, 2026
PAI Holdings, LLC dba PAI PharmaACETAMINOPHEN 300 mg/12.5mL; CODEINE PHOSPHATE 30 mg/12.5mLJul 15, 2026Sep 3, 2026
Genus Lifesciences Inc.ACETAMINOPHEN 120 mg/5mL; CODEINE PHOSPHATE 12 mg/5mLJul 15, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Acetaminophen and Codeine Phosphate — NDC 64950-0374-16," retrieved September 3, 2026, https://drugdashboards.com/drug/64950037416.

Free to cite with attribution — see how the data is put together.