DrugDashboards

Atovaquone and Proguanil Hydrochloride

Atovaquone and Proguanil Hydrochloride · ATOVAQUONE 250 mg/1; PROGUANIL HYDROCHLORIDE 100 mg/1 · Tablet, Film Coated · Oral · Glenmark Pharmaceuticals Inc.,USA

NDC 68462-0404-67 · 2 BLISTER PACK in 1 CARTON / 12 TABLET, FILM COATED in 1 BLISTER PACK · ANDA · View full market →

The short version

10 companies supply this market — deep enough that no single failure threatens the supply. The price is down 17% over the past year, to $1.48 per unit. One of its named manufacturing plants, Glenmark Pharmaceuticals Limited, failed FDA inspectionwithin the last two years — the agency’s most serious outcome. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$1.48per EAinvoice-surveyed acquisition cost · Aug 19, 2026
  • Part D point of sale (median)$2.79per unitnegotiated price across 5,496 plans — before rebates · Apr 1, 2026
  • Medicaid generic ceiling (FUL)$1.48per TABweighted avg manufacturer price $0.8045 · Aug 1, 2026100% of what pharmacies pay — higher than 10% of drugs with this benchmark

Medicare Part D

All Part D pricing →
ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$2.79per unit
middle half $1.79$3.40 · 5,496 plans · Apr 1, 2026
Est. net of rebates
≈ $2.79
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
100%of plans cover it
tier 4 · prior auth 0% · step therapy 0% · qty limit 0%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.

NADAC price per unit

$0$2.00$4.00$6.00Nov 2013Sep 2026$1.48
154 price points · per EA · dashed = manufacturer avg (WAMP)Source: CMS NADAC

Estimated fill cost

#30 count
$44.33
#90 count
$132.99

Estimates: latest NADAC unit price × quantity. Pharmacy acquisition cost only — excludes dispensing fees, markup, and insurance terms.

Medicaid spend (2025)

$541,739
7,991 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

0Low risk

Nothing here is signaling trouble: several manufacturers, no current shortage, no recent serious recalls, stable pricing. In drug supply, boring is the good outcome.

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.2%chance of a new FDA shortage posting for atovaquone and proguanil hydrochloride (oral solid) in the next 90 days

OAI inspection at a producing facility (24 months) · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Regulatory

Application
ANDA091211
TE code
AB
Approval date
Jan 12, 2011
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Atovaquone and Proguanil Hydrochloride (Tablet, Film Coated)

LabelerStrengthFirst seenLast seen
A-S Medication SolutionsATOVAQUONE 250 mg/1; PROGUANIL HYDROCHLORIDE 100 mg/1Jul 15, 2026Sep 2, 2026
BluePoint LaboratoriesATOVAQUONE 250 mg/1; PROGUANIL HYDROCHLORIDE 100 mg/1Jul 15, 2026Sep 2, 2026
Bora Pharmaceutical Services Inc.ATOVAQUONE 62.5 mg/1; PROGUANIL HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Bora Pharmaceutical Services Inc.ATOVAQUONE 250 mg/1; PROGUANIL HYDROCHLORIDE 100 mg/1Jul 15, 2026Sep 2, 2026
GlaxoSmithKline LLCATOVAQUONE 250 mg/1; PROGUANIL HYDROCHLORIDE 100 mg/1Jul 15, 2026Sep 2, 2026
GlaxoSmithKline LLCATOVAQUONE 62.5 mg/1; PROGUANIL HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Glenmark Pharmaceuticals Inc.,USAATOVAQUONE 250 mg/1; PROGUANIL HYDROCHLORIDE 100 mg/1Jul 15, 2026Sep 2, 2026
Golden State Medical Supply, Inc.ATOVAQUONE 250 mg/1; PROGUANIL HYDROCHLORIDE 100 mg/1Jul 15, 2026Sep 2, 2026
Mylan Pharmaceuticals Inc.ATOVAQUONE 62.5 mg/1; PROGUANIL HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Mylan Pharmaceuticals Inc.ATOVAQUONE 250 mg/1; PROGUANIL HYDROCHLORIDE 100 mg/1Jul 15, 2026Sep 2, 2026
Prasco LaboratoriesATOVAQUONE 250 mg/1; PROGUANIL HYDROCHLORIDE 100 mg/1Jul 15, 2026Sep 2, 2026
Proficient Rx LPATOVAQUONE 250 mg/1; PROGUANIL HYDROCHLORIDE 100 mg/1Jul 15, 2026Sep 2, 2026
Bryant Ranch PrepackATOVAQUONE 250 mg/1; PROGUANIL HYDROCHLORIDE 100 mg/1Aug 1, 2026Aug 29, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Atovaquone and Proguanil Hydrochloride — NDC 68462-0404-67," retrieved September 3, 2026, https://drugdashboards.com/drug/68462040467.

Free to cite with attribution — see how the data is put together.