DrugDashboards

Diphenhydramine Hydrochloride

Diphenhydramine Hydrochloride · DIPHENHYDRAMINE HYDROCHLORIDE 50 mg/mL · Injection, Solution · Intramuscular; Intravenous · Fresenius Kabi USA, LLC

NDC 76045-0102-10 · 24 BLISTER PACK in 1 CARTON / 1 SYRINGE, GLASS in 1 BLISTER PACK / 1 mL in 1 SYRINGE, GLASS · ANDA · View full market →

The short version

9 companies supply this market — a reasonable cushion if one runs into trouble. Historically, drugs in this position went on to a new shortage within 90 days about 0.4% of the time — roughly 3× the typical drug (0.1%).

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Medicare Part B pays (ASP+6%)$0.7520per billing unit (50 MG)HCPCS J1200 · Jul 1, 2026
  • Federal contracts pay (FSS)$44.38per package of 24X1MLFresenius Kabi, LLC · May 15, 2025

Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.

Estimated fill cost

WAC per package, as filed
$62.40
Reported to Texas DSHS · 2026 annual filing · Fresenius Kabi USA

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicare Part B (ASP)

Payment limit per 50 MG
$0.752
HCPCS J1200 · Jul 1, 2026 quarter · typically ASP + 6%

Medicaid spend (2025)

$47,218
3,879 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

Not scored — fragility is computed for NADAC-priced NDCs.

90-day shortage risk (model v2)

0.4%chance of a new FDA shortage posting for diphenhydramine hydrochloride (injectable) in the next 90 days

sterile injectable · sole-source market · price up 5% YoY

For scale: the typical drug’s chance is about 0.1% — this one is 3× that.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

  • Part D specialty tier
  • Costs ≥ $950/fill
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program

Regulatory

Application
ANDA091526
TE code
AP
Approval date
Mar 26, 2013
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Diphenhydramine Hydrochloride (Injection, Solution)

LabelerStrengthFirst seenLast seen
Fresenius Kabi USA, LLCDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/mLJul 15, 2026Sep 3, 2026
HF Acquisition Co LLC, DBA HealthFirstDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/mLJul 15, 2026Sep 3, 2026
Micro Labs LimitedDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/mLJul 15, 2026Sep 3, 2026
Armas Pharmaceuticals Inc.DIPHENHYDRAMINE HYDROCHLORIDE 50 mg/mLJul 15, 2026Sep 2, 2026
Avenacy, LLCDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/mLJul 15, 2026Sep 2, 2026
Cardinal Health 107, LLCDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/mLJul 15, 2026Sep 2, 2026
Medical Purchasing Solutions, LLCDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/mLJul 15, 2026Sep 2, 2026
ProPharma DistributionDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/mLJul 15, 2026Sep 2, 2026
Sagent PharmaceuticalsDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/mLJul 15, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Diphenhydramine Hydrochloride — NDC 76045-0102-10," retrieved September 3, 2026, https://drugdashboards.com/drug/76045010210.

Free to cite with attribution — see how the data is put together.