The short version
Only one company currently supplies this market — there is no backup if it stumbles. It is in shortage right now.
Market view
methotrexate sodium · Injection, Powder, Lyophilized, For Solution
1 marketed package NDCs · 1 active manufacturer
Most dispensed: 2.5 mg · Tablet · #100 tablets/bottle, plastic · 2.5 mg · Tablet · #100 tablets/bottle · 25 mg/mL · Injection, Solution · #1 vial/carton / 10 ml in 1 vial · 2.5 mg · Tablet · #36 tablets/bottle
What changed in the last 90 days
Every detected change for methotrexate sodium, newest first — price moves, shortages, recalls, and manufacturers entering or leaving. Detected by comparing each day’s federal data against the day before.
- Methotrexate SodiumAug 19, 2026Price downNADAC $0.15836 → $0.15658 per unit (-1.12%)
- MethotrexateAug 19, 2026Price downNADAC $3.24725 → $3.1283 per unit (-3.66%)
- MethotrexateAug 19, 2026Price downNADAC $0.15836 → $0.15658 per unit (-1.12%)
- MethotrexateAug 19, 2026Price downNADAC $0.15836 → $0.15658 per unit (-1.12%)
- Methotrexate SodiumAug 19, 2026Price downNADAC $0.15836 → $0.15658 per unit (-1.12%)
- MethotrexateJul 22, 2026Price downNADAC $3.26336 → $3.24725 per unit (-0.49%)
- Methotrexate SodiumJul 22, 2026Price downNADAC $0.16347 → $0.15836 per unit (-3.13%)
- MethotrexateJul 22, 2026Price downNADAC $0.16347 → $0.15836 per unit (-3.13%)
- MethotrexateJul 22, 2026Price downNADAC $0.16347 → $0.15836 per unit (-3.13%)
- Methotrexate SodiumJul 22, 2026Price downNADAC $0.16347 → $0.15836 per unit (-3.13%)
Same drug class
Other molecules FDA puts in Folate Analog Metabolic Inhibitor, with whether each is in shortage right now. Same class is not the same drug — substitution is a clinical decision, and this is a supply picture, not a recommendation.
Common questions
- Is Methotrexate sodium in shortage right now?
- Yes. FDA currently lists Methotrexate sodium in shortage. This page is rebuilt every morning from FDA's shortage database.
- Who makes Methotrexate sodium?
- 8 companies have marketed Methotrexate sodium in the last 30 days, according to the FDA NDC Directory. Every manufacturer and package is listed on this page.
- What does Methotrexate sodium cost?
- The typical pharmacy pays about $0.1566 per unit, based on the most recent CMS NADAC survey of actual acquisition costs. That is what the pharmacy pays for the drug itself — not the cash price, and not what an insurer is billed.
Shortage reports for this molecule
- In shortage now — Methotrexate Preservative Free, Injection, 1 g (NDC 63323-122-50)Mar 13, 2023
All marketed products
Expand a strength to see its dosage forms, then package sizes, then each manufacturer and NDC. Click an NDC for its full detail page.