The short version
Just 3 companies supply this market — thin enough that a single exit would be felt immediately.
Market view
neostigmine methylsulfate · Injection, Solution
10 marketed package NDCs · 3 active manufacturers
Most dispensed: 1 mg/mL · Injection · #10 vial, multi-doses/carton / 10 ml in 1 vial, multi-dose · .5 mg/mL · Injection · #10 vial, multi-doses/carton / 10 ml in 1 vial, multi-dose · 1 mg/mL · Injection · #1 vial, multi-dose/bag / 10 ml in 1 vial, multi-dose · 1 mg/mL · Injection, Solution · #10 blister packs/carton / 1 syringe, glass in 1 blister pack / 3 ml in 1 syringe, glass
Same drug class
Other molecules FDA puts in Cholinesterase Inhibitor, with whether each is in shortage right now. Same class is not the same drug — substitution is a clinical decision, and this is a supply picture, not a recommendation.
- bridged ring combination· 1 maker
- malathion· 1 maker
- memantine and donepezil hydrochlorides· 1 maker
- neostigmine methylsulfate and glycopyrrolate· 1 maker
- pop detox· 1 maker
- pyridostigmine bromide oral· 1 maker
- memantine hydrochloride and donepezil hydrochloride· 2 makers
- neostigmine· 2 makers
- memantine and donepezil· 3 makers
- galantamine· 8 makers
- galantamine hydrobromide· 8 makers
- rivastigmine· 17 makers
Common questions
- Is Neostigmine methylsulfate in shortage right now?
- No. FDA does not currently list Neostigmine methylsulfate in shortage. This page is rebuilt every morning from FDA's shortage database, so a new posting appears here the day it is published.
- Who makes Neostigmine methylsulfate?
- 31 companies have marketed Neostigmine methylsulfate in the last 30 days, according to the FDA NDC Directory. Every manufacturer and package is listed on this page.
Shortage reports for this molecule
- Planned discontinuation — Neostigmine Methylsulfate, Injection, .5 mg/1 mL (NDC 63323-413-10)Jan 12, 2026
All marketed products
Expand a strength to see its dosage forms, then package sizes, then each manufacturer and NDC. Click an NDC for its full detail page.