The short version
28 companies supply this market — deep enough that no single failure threatens the supply. The price has held steady around $0.0167 per mL over the past year.
Market view
diphenhydramine hcl · Liquid
50 marketed package NDCs · 28 active manufacturers
Most dispensed: DIPHENHYDRAMINE HYDROCHLORIDE 25 mg · Tablet, Film Coated · #2 blister packs/carton / 12 tablet, film coated in 1 blister pack · DIPHENHYDRAMINE HYDROCHLORIDE 25 mg · Tablet, Film Coated · #1 bottle, plastic/carton / 100 tablet, film coated in 1 bottle, plastic · DIPHENHYDRAMINE HYDROCHLORIDE 50 mg · Capsule · #1 bottle, plastic/box / 32 capsule in 1 bottle, plastic · DIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mL · Solution · #1 bottle, plastic/carton / 118 ml in 1 bottle, plastic
Price range and competition
RSS: changes for this drugEvery company selling this drug reports its own price. The line follows the middle of the pack; the shaded band holds the middle half of companies — the wider it is, the more they disagree.
Latest · Sep 2026 — typical price $0.0167 · middle half $0.016–$0.0191 · full range $0.0136–$0.0199 · 6 products · 27 companies
ⓘ How this was built
Data sources
- CMS NADAC weekly survey + monthly archives back to 2013 (data.medicaid.gov)
- CMS Federal Upper Limit files (weighted AMP)
- FDA NDC Directory (openFDA) — maker roster
Method
Each month's band spans the NADAC unit prices of every NDC of this drug (min, quartiles, median, max), split into brand and generic cohorts by FDA marketing category. Maker counts come from distinct labelers with the NDC actively listed.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
What changed in the last 90 days
Every detected change for diphenhydramine hcl, newest first — price moves, shortages, recalls, and manufacturers entering or leaving. Detected by comparing each day’s federal data against the day before.
- Allergy ReliefAug 19, 2026Price downNADAC $0.05574 → $0.05416 per unit (-2.83%)
- Sleep AidAug 19, 2026Price downNADAC $0.12039 → $0.11709 per unit (-2.74%)
- Diphenhydramine HClAug 19, 2026Price upNADAC $0.03073 → $0.03131 per unit (+1.89%)
- Diphenhydramine HClAug 19, 2026Price upNADAC $0.03073 → $0.03131 per unit (+1.89%)
- Diphenhydramine HClAug 19, 2026Price downNADAC $0.05574 → $0.05416 per unit (-2.83%)
- Diphenhydramine HClAug 19, 2026Price downNADAC $0.05574 → $0.05416 per unit (-2.83%)
- Sleep AidAug 19, 2026Price downNADAC $0.12039 → $0.11709 per unit (-2.74%)
- Nighttime Sleep AidAug 19, 2026Price upNADAC $0.05545 → $0.06028 per unit (+8.71%)
- Allergy ReliefAug 19, 2026Price downNADAC $0.05574 → $0.05416 per unit (-2.83%)
- Allergy ReliefAug 19, 2026Price downNADAC $0.05574 → $0.05416 per unit (-2.83%)
Same drug class
Other molecules FDA puts in Histamine-1 Receptor Antagonist, with whether each is in shortage right now. Same class is not the same drug — substitution is a clinical decision, and this is a supply picture, not a recommendation.
- 430r walgreens acetaminophen 500 mg,diphenhydramine hcl 25 mg tablet· 1 maker
- acetaminophen , diphenhydramine hcl,phenylephrine hcl· 1 maker
- acetaminophen , diphenhydramine hydrochloride,phenylephrine hydrochloride· 1 maker
- acetaminophen 325 mg, diphenhydramine hcl 12.5 mg, phenylephrine hcl 5 mg· 1 maker
- acetaminophen 500 mg and diphenhydramine hcl 25 mg· 1 maker
- acetaminophen 500 mg,diphenhydramine hydrochloride 25 mg tablet· 1 maker
- acetaminophen 500mg / diphenhydramine hcl 25mg· 1 maker
- acetaminophen 500mg/ diphenhydramine hcl 25mg· 1 maker
- acetaminophen chlorpheniramine maleate dextromethorphan hydrobromide phenylepherine hydrochloride· 1 maker
- acetaminophen phenylephrine hcl chlorpheniramine maleate· 1 maker
- acetaminophen-chlorpheniramine maleate-dextromethorphan hbr-guaifenesin-phenylephrine hcl· 1 maker
- acetaminophen-dextromethorphan hbr-phenylephrine hcl-chlorpheniramine maleate· 1 maker
Common questions
- Is Diphenhydramine hcl in shortage right now?
- No. FDA does not currently list Diphenhydramine hcl in shortage. This page is rebuilt every morning from FDA's shortage database, so a new posting appears here the day it is published.
- Who makes Diphenhydramine hcl?
- 149 companies have marketed Diphenhydramine hcl in the last 30 days, according to the FDA NDC Directory. Every manufacturer and package is listed on this page.
- What does Diphenhydramine hcl cost?
- The typical pharmacy pays about $0.0374 per unit, based on the most recent CMS NADAC survey of actual acquisition costs. That is what the pharmacy pays for the drug itself — not the cash price, and not what an insurer is billed.
All marketed products
Expand a strength to see its dosage forms, then package sizes, then each manufacturer and NDC. Click an NDC for its full detail page.