The short version
Just 2 companies supply this market — thin enough that a single exit would be felt immediately.
Market view
diphenhydramine hcl · Powder
4 marketed package NDCs · 2 active manufacturers
Most dispensed: DIPHENHYDRAMINE HYDROCHLORIDE 25 mg · Tablet, Film Coated · #2 blister packs/carton / 12 tablet, film coated in 1 blister pack · DIPHENHYDRAMINE HYDROCHLORIDE 25 mg · Tablet, Film Coated · #1 bottle, plastic/carton / 100 tablet, film coated in 1 bottle, plastic · DIPHENHYDRAMINE HYDROCHLORIDE 50 mg · Capsule · #1 bottle, plastic/box / 32 capsule in 1 bottle, plastic · DIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mL · Solution · #1 bottle, plastic/carton / 118 ml in 1 bottle, plastic
What changed in the last 90 days
Every detected change for diphenhydramine hcl, newest first — price moves, shortages, recalls, and manufacturers entering or leaving. Detected by comparing each day’s federal data against the day before.
- Allergy ReliefAug 19, 2026Price downNADAC $0.05574 → $0.05416 per unit (-2.83%)
- Sleep AidAug 19, 2026Price downNADAC $0.12039 → $0.11709 per unit (-2.74%)
- Diphenhydramine HClAug 19, 2026Price upNADAC $0.03073 → $0.03131 per unit (+1.89%)
- Diphenhydramine HClAug 19, 2026Price upNADAC $0.03073 → $0.03131 per unit (+1.89%)
- Diphenhydramine HClAug 19, 2026Price downNADAC $0.05574 → $0.05416 per unit (-2.83%)
- Diphenhydramine HClAug 19, 2026Price downNADAC $0.05574 → $0.05416 per unit (-2.83%)
- Sleep AidAug 19, 2026Price downNADAC $0.12039 → $0.11709 per unit (-2.74%)
- Nighttime Sleep AidAug 19, 2026Price upNADAC $0.05545 → $0.06028 per unit (+8.71%)
- Allergy ReliefAug 19, 2026Price downNADAC $0.05574 → $0.05416 per unit (-2.83%)
- Allergy ReliefAug 19, 2026Price downNADAC $0.05574 → $0.05416 per unit (-2.83%)
Same drug class
Other molecules FDA puts in Histamine-1 Receptor Antagonist, with whether each is in shortage right now. Same class is not the same drug — substitution is a clinical decision, and this is a supply picture, not a recommendation.
- 430r walgreens acetaminophen 500 mg,diphenhydramine hcl 25 mg tablet· 1 maker
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- acetaminophen 325 mg, diphenhydramine hcl 12.5 mg, phenylephrine hcl 5 mg· 1 maker
- acetaminophen 500 mg and diphenhydramine hcl 25 mg· 1 maker
- acetaminophen 500 mg,diphenhydramine hydrochloride 25 mg tablet· 1 maker
- acetaminophen 500mg / diphenhydramine hcl 25mg· 1 maker
- acetaminophen 500mg/ diphenhydramine hcl 25mg· 1 maker
- acetaminophen chlorpheniramine maleate dextromethorphan hydrobromide phenylepherine hydrochloride· 1 maker
- acetaminophen phenylephrine hcl chlorpheniramine maleate· 1 maker
- acetaminophen-chlorpheniramine maleate-dextromethorphan hbr-guaifenesin-phenylephrine hcl· 1 maker
- acetaminophen-dextromethorphan hbr-phenylephrine hcl-chlorpheniramine maleate· 1 maker
Common questions
- Is Diphenhydramine hcl in shortage right now?
- No. FDA does not currently list Diphenhydramine hcl in shortage. This page is rebuilt every morning from FDA's shortage database, so a new posting appears here the day it is published.
- Who makes Diphenhydramine hcl?
- 149 companies have marketed Diphenhydramine hcl in the last 30 days, according to the FDA NDC Directory. Every manufacturer and package is listed on this page.
- What does Diphenhydramine hcl cost?
- The typical pharmacy pays about $0.0374 per unit, based on the most recent CMS NADAC survey of actual acquisition costs. That is what the pharmacy pays for the drug itself — not the cash price, and not what an insurer is billed.
All marketed products
Expand a strength to see its dosage forms, then package sizes, then each manufacturer and NDC. Click an NDC for its full detail page.