The short version
11 companies supply this market — deep enough that no single failure threatens the supply.
Market view
promethazine hydrochloride · Powder
30 marketed package NDCs · 11 active manufacturers
Most dispensed: 25 mg · Tablet · #100 tablets/bottle · 50 mg · Tablet · #100 tablets/bottle · 12.5 mg · Tablet · #100 tablets/bottle · 25 mg · Tablet · #1000 tablets/bottle
What changed in the last 90 days
Every detected change for promethazine hydrochloride, newest first — price moves, shortages, recalls, and manufacturers entering or leaving. Detected by comparing each day’s federal data against the day before.
- Promethazine HydrochlorideAug 19, 2026Price upNADAC $0.04164 → $0.04218 per unit (+1.3%)
- Promethazine HydrochlorideAug 19, 2026Price upNADAC $0.07719 → $0.07863 per unit (+1.87%)
- Promethazine HydrochlorideAug 19, 2026Price downNADAC $0.04552 → $0.04544 per unit (-0.18%)
- Promethazine HydrochlorideAug 19, 2026Price downNADAC $0.04552 → $0.04544 per unit (-0.18%)
- Promethazine HydrochlorideAug 19, 2026Price downNADAC $0.04552 → $0.04544 per unit (-0.18%)
- Promethazine HydrochlorideAug 19, 2026Price upNADAC $0.04992 → $0.05342 per unit (+7.01%)
- Promethazine HydrochlorideAug 19, 2026Price downNADAC $0.04552 → $0.04544 per unit (-0.18%)
- Promethazine HydrochlorideAug 19, 2026Price upNADAC $0.07719 → $0.07863 per unit (+1.87%)
- Promethazine HydrochlorideAug 19, 2026Price downNADAC $0.04552 → $0.04544 per unit (-0.18%)
- Promethazine HydrochlorideAug 19, 2026Price downNADAC $0.04552 → $0.04544 per unit (-0.18%)
Same drug class
Other molecules FDA puts in Phenothiazine, with whether each is in shortage right now. Same class is not the same drug — substitution is a clinical decision, and this is a supply picture, not a recommendation.
- promethazine· in shortage
- aceticum ac, acetylsal ac, adrenocorticotrophin, alumina, arsenicum alb, borago, ceanothus, chelidonium maj, chionanthus, chloramphenicolum, chlorpromazinum, cholesterinum, cortisone aceticum, damiana, folliculinum, fumaricum ac, kali iod, lycopodium, nat sulphuricum, nux vom, oleum morrhuae, petroleum, phenacetinum, phosphoricum ac, phosphorus, plumb met, saccharum off, silicea, taraxacum, thyroidinum.· 1 maker
- homeopathic liquid· 1 maker
- perphenazine and amitriptyline hydrochloride· 1 maker
- promethazine and phenylephrine· 1 maker
- promethazine hci· 1 maker
- promethazine hcl· 1 maker
- promethazine hydrochloride and dextromethorphan hydrobromide oral· 1 maker
- promethazine hydrochloride and phenylephrine hydrochloride· 1 maker
- promethazine, phenylephrine, codeine· 1 maker
- chlorpromazine hci· 2 makers
- chlorpromazine· 4 makers
Common questions
- Is Promethazine hydrochloride in shortage right now?
- Yes. FDA currently lists Promethazine hydrochloride in shortage. This page is rebuilt every morning from FDA's shortage database.
- Who makes Promethazine hydrochloride?
- 54 companies have marketed Promethazine hydrochloride in the last 30 days, according to the FDA NDC Directory. Every manufacturer and package is listed on this page.
- What does Promethazine hydrochloride cost?
- The typical pharmacy pays about $0.0534 per unit, based on the most recent CMS NADAC survey of actual acquisition costs. That is what the pharmacy pays for the drug itself — not the cash price, and not what an insurer is billed.
All marketed products
Expand a strength to see its dosage forms, then package sizes, then each manufacturer and NDC. Click an NDC for its full detail page.