The short version
17 companies supply this market — deep enough that no single failure threatens the supply. The price is up 30% over the past year, to $0.0241 per mL.
Market view
acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride · Solution
33 marketed package NDCs · 17 active manufacturers
Most dispensed: 325 mg/15mL; 10 mg/15mL; 200 mg/15mL; 5 mg/15mL · Solution · #355 mL/bottle · 325 mg; 10 mg; 200 mg; 5 mg · Tablet, Film Coated · #12 blister packs/carton / 2 tablet, film coated in 1 blister pack · 650 mg/20mL; 20 mg/20mL; 400 mg/20mL; 10 mg/20mL · Solution · #1 bottle/carton / 118 ml in 1 bottle · 325 mg; 10 mg; 200 mg; 5 mg · Tablet, Film Coated · #6 blister packs/carton / 2 tablet, film coated in 1 blister pack
Price range and competition
RSS: changes for this drugEvery company selling this drug reports its own price. The line follows the middle of the pack; the shaded band holds the middle half of companies — the wider it is, the more they disagree.
Latest · Sep 2026 — typical price $0.0241 · middle half $0.0241–$0.0241 · full range $0.0241–$0.0241 · 1 products · 17 companies
ⓘ How this was built
Data sources
- CMS NADAC weekly survey + monthly archives back to 2013 (data.medicaid.gov)
- CMS Federal Upper Limit files (weighted AMP)
- FDA NDC Directory (openFDA) — maker roster
Method
Each month's band spans the NADAC unit prices of every NDC of this drug (min, quartiles, median, max), split into brand and generic cohorts by FDA marketing category. Maker counts come from distinct labelers with the NDC actively listed.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
What changed in the last 90 days
Every detected change for acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride, newest first — price moves, shortages, recalls, and manufacturers entering or leaving. Detected by comparing each day’s federal data against the day before.
- HyVee Daytime Severe Cold and Flu SOFTGELSep 3, 2026Mfr enteredHyVee Inc · acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride
- HyVee Daytime Severe Cold and Flu SOFTGELSep 3, 2026New productHyVee Inc
- Medi-First Plus Cough ColdSep 2, 2026Mfr exitedUnifirst First Aid Corporation · acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride
- Medique at Home Decorel ForteSep 2, 2026Mfr exitedUnifirst First Aid Corporation · acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride
- Medique at Home Decorel ForteSep 2, 2026Mfr exitedSportpharm LLC · acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride
- Physicians Care Non-Drowsy Cold and CoughSep 2, 2026Mfr exitedAcme United · acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride
- Maximum Strength Cold, Flu And Sore ThroatSep 2, 2026Mfr exitedCVS Pharmacy, Inc. · acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride
- Medique Decorel ForteAug 26, 2026Mfr enteredUnifirst First Aid Corporation · acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride
- Medi-First Plus Cough ColdAug 26, 2026Mfr enteredUnifirst First Aid Corporation · acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride
- Medique at Home Decorel ForteAug 26, 2026Mfr enteredUnifirst First Aid Corporation · acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride
Same drug class
Other molecules FDA puts in Uncompetitive N-methyl-D-aspartate Receptor Antagonist, with whether each is in shortage right now. Same class is not the same drug — substitution is a clinical decision, and this is a supply picture, not a recommendation.
- acetaminohpen, dextromethorphan hydrobromide· 1 maker
- acetaminophen 325 mg and dextromethorphan hbr 10 mg oral liquid day time kids· 1 maker
- acetaminophen 325 mg dextromethorphan hbr 10 mg phenylephrine hci 5 mg· 1 maker
- acetaminophen 325 mg dextromethorphan hbr 15 mg doxylamine succinate 6.25 mg· 1 maker
- acetaminophen 325 mg, dextromethorphan hbr 15 mg, doxylamine succinate 6.25 mg· 1 maker
- acetaminophen 650 mg, dextromethorphan hbr 20 mg, guaifenesin 400 mg, phenylephrine hcl 10 mg· 1 maker
- acetaminophen chlorpheniramine maleate dextromethorphan hydrobromide phenylepherine hydrochloride· 1 maker
- acetaminophen dextromethorphan hbr doxylamine succinate phenylephrine hci· 1 maker
- acetaminophen dextromethorphan hbr guaifenesin, phenylephrine hcl· 1 maker
- acetaminophen-chlorpheniramine maleate-dextromethorphan hbr-guaifenesin-phenylephrine hcl· 1 maker
- acetaminophen-dextromethorphan hbr-phenylephrine hcl-chlorpheniramine maleate· 1 maker
- acetaminophen, chlorpheniramine malaeate, dextromethorphan hydrobromide, phenylephrine hydrochloride· 1 maker
Common questions
- Is Acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride in shortage right now?
- No. FDA does not currently list Acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride in shortage. This page is rebuilt every morning from FDA's shortage database, so a new posting appears here the day it is published.
- Who makes Acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride?
- 42 companies have marketed Acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride in the last 30 days, according to the FDA NDC Directory. Every manufacturer and package is listed on this page.
- What does Acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride cost?
- The typical pharmacy pays about $0.1412 per unit, based on the most recent CMS NADAC survey of actual acquisition costs. That is what the pharmacy pays for the drug itself — not the cash price, and not what an insurer is billed.
All marketed products
Expand a strength to see its dosage forms, then package sizes, then each manufacturer and NDC. Click an NDC for its full detail page.