DrugDashboards

Market view

acetaminophen, diphenhydramine hcl · Tablet, Coated

43 marketed package NDCs · 23 active manufacturers

Most dispensed: 500 mg; DIPHENHYDRAMINE HYDROCHLORIDE 25 mg · Tablet, Coated · #1 bottle, plastic/box / 50 tablet, coated in 1 bottle, plastic · 500 mg; DIPHENHYDRAMINE HYDROCHLORIDE 25 mg · Tablet, Coated · #1 bottle, plastic/carton / 20 tablet, coated in 1 bottle, plastic · 500 mg; DIPHENHYDRAMINE HYDROCHLORIDE 25 mg · Tablet, Film Coated · #1 bottle/carton / 50 tablet, film coated in 1 bottle · 500 mg; DIPHENHYDRAMINE HYDROCHLORIDE 25 mg · Tablet · #1 bottle/carton / 50 tablet in 1 bottle

All formsTablet, Coated (43)Tablet, Film Coated (25)Tablet (13)Kit (6)Liquid (4)Solution (3)Powder, For Solution (3)Syrup (1)Capsule, Liquid Filled (1)Tablet, Chewable (1)Capsule, Gelatin Coated (1)

The short version

23 companies supply this market — deep enough that no single failure threatens the supply. The price has held steady around $0.0444 per unit over the past year.

Price range and competition

RSS: changes for this drug

Every company selling this drug reports its own price. The line follows the middle of the pack; the shaded band holds the middle half of companies — the wider it is, the more they disagree.

$0$0.02$0.04$0.06Apr 2016Sep 2026023companies actively selling

Latest · Sep 2026 — typical price $0.0444 · middle half $0.0444–$0.0444 · full range $0.0444–$0.0444 · 2 products · 22 companies

middle half of companies’ pricestypical (median) pricecompanies actively selling (bottom lane)Priced per unitⓘSource: CMS NADAC
ⓘ How this was built
Data sources
  • CMS NADAC weekly survey + monthly archives back to 2013 (data.medicaid.gov)
  • CMS Federal Upper Limit files (weighted AMP)
  • FDA NDC Directory (openFDA) — maker roster
Method

Each month's band spans the NADAC unit prices of every NDC of this drug (min, quartiles, median, max), split into brand and generic cohorts by FDA marketing category. Maker counts come from distinct labelers with the NDC actively listed.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

What changed in the last 90 days

Every detected change for acetaminophen, diphenhydramine hcl, newest first — price moves, shortages, recalls, and manufacturers entering or leaving. Detected by comparing each day’s federal data against the day before.

Same drug class

Other molecules FDA puts in Histamine-1 Receptor Antagonist, with whether each is in shortage right now. Same class is not the same drug — substitution is a clinical decision, and this is a supply picture, not a recommendation.

Common questions

Is Acetaminophen, diphenhydramine hcl in shortage right now?
No. FDA does not currently list Acetaminophen, diphenhydramine hcl in shortage. This page is rebuilt every morning from FDA's shortage database, so a new posting appears here the day it is published.
Who makes Acetaminophen, diphenhydramine hcl?
49 companies have marketed Acetaminophen, diphenhydramine hcl in the last 30 days, according to the FDA NDC Directory. Every manufacturer and package is listed on this page.
What does Acetaminophen, diphenhydramine hcl cost?
The typical pharmacy pays about $0.0444 per unit, based on the most recent CMS NADAC survey of actual acquisition costs. That is what the pharmacy pays for the drug itself — not the cash price, and not what an insurer is billed.

All marketed products

Expand a strength to see its dosage forms, then package sizes, then each manufacturer and NDC. Click an NDC for its full detail page.