The short version
5 companies supply this market — a reasonable cushion if one runs into trouble. The price is up 14% over the past year, to $0.2721 per mL. It is in shortage right now — FDA lists the reason as “demand increase for the drug”.
Market view
lidocaine hydrochloride,epinephrine bitartrate
18 marketed package NDCs · 5 active manufacturers
Most dispensed: LIDOCAINE HYDROCHLORIDE ANHYDROUS 10 mg/mL; EPINEPHRINE BITARTRATE .01 mg/mL · Injection, Solution · #25 vial, multi-doses/tray / 20 ml in 1 vial, multi-dose · LIDOCAINE HYDROCHLORIDE ANHYDROUS 20 mg/mL; EPINEPHRINE BITARTRATE .01 mg/mL · Injection, Solution · #25 vial, multi-doses/tray / 20 ml in 1 vial, multi-dose
Price range and competition
RSS: changes for this drugEvery company selling this drug reports its own price. The line follows the middle of the pack; the shaded band holds the middle half of companies — the wider it is, the more they disagree.
Latest · Aug 2025 — typical price $0.2721 · middle half $0.2688–$0.2721 · full range $0.2655–$0.2721 · 3 products · 5 companies
ⓘ How this was built
Data sources
- CMS NADAC weekly survey + monthly archives back to 2013 (data.medicaid.gov)
- CMS Federal Upper Limit files (weighted AMP)
- FDA NDC Directory (openFDA) — maker roster
Method
Each month's band spans the NADAC unit prices of every NDC of this drug (min, quartiles, median, max), split into brand and generic cohorts by FDA marketing category. Maker counts come from distinct labelers with the NDC actively listed.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
What changed in the last 90 days
Every detected change for lidocaine hydrochloride,epinephrine bitartrate, newest first — price moves, shortages, recalls, and manufacturers entering or leaving. Detected by comparing each day’s federal data against the day before.
- XylocaineSep 2, 2026Mfr exitedFresenius Kabi USA, LLC · lidocaine hydrochloride,epinephrine bitartrate
- XylocaineSep 2, 2026Mfr exitedA-S Medication Solutions · lidocaine hydrochloride,epinephrine bitartrate
- XylocaineSep 2, 2026Mfr exitedSportpharm LLC · lidocaine hydrochloride,epinephrine bitartrate
- XylocaineSep 2, 2026Mfr exitedRemedyrepack Inc. · lidocaine hydrochloride,epinephrine bitartrate
- XylocaineSep 2, 2026Mfr exitedProPharma Distribution · lidocaine hydrochloride,epinephrine bitartrate
- XylocaineSep 2, 2026Mfr exitedFresenius Kabi USA, LLC · lidocaine hydrochloride,epinephrine bitartrate
- Xylocaine MPFSep 2, 2026Mfr exitedFresenius Kabi USA, LLC · lidocaine hydrochloride,epinephrine bitartrate
- Xylocaine MPFSep 2, 2026Mfr exitedFresenius Kabi USA, LLC · lidocaine hydrochloride,epinephrine bitartrate
- XylocaineAug 26, 2026Mfr enteredFresenius Kabi USA, LLC · lidocaine hydrochloride,epinephrine bitartrate
- XylocaineAug 26, 2026Mfr enteredFresenius Kabi USA, LLC · lidocaine hydrochloride,epinephrine bitartrate
Same drug class
Other molecules FDA puts in beta-Adrenergic Agonist, with whether each is in shortage right now. Same class is not the same drug — substitution is a clinical decision, and this is a supply picture, not a recommendation.
- bupivacaine hydrochloride and epinephrine· in shortage
- dobutamine hydrochloride· in shortage
- dobutamine· in shortage
- bupivacaine hydrochloride and epinephrine bitartrate· in shortage
- lidocaine hydrochloride and epinephrine· in shortage
- epinephrine· in shortage
- lidocaine hydrochloride· in shortage
- .alpha.-ketoglutaric acid - ambergris - anamirta cocculus seed - conium maculatum flowering top - epinephrine - fumaric acid - malic acid - melatonin - mineral oil - pteridium aquilinum root - pyridoxine hydrochloride - quinhydrone - quinine - sus scrofa artery - sus scrofa cerebellum - sus scrofa placenta - thiamine hydrochloride - tobacco leaf -· 1 maker
- acer negundo, acer rubrum, adrenalinum, allium cepa, arsenicum iodatum, betula nigra, euphrasia officinalis, fraxinus americana, histaminum hydrochloricum, ligustrum vulgare, liquidambar styraciflua, morus alba, pinus strobus, populus deltoides, quercus rubra, sabadilla, salix nigra, sanguinaria canadensis· 1 maker
- aceticum ac, adrenalinum, adrenocorticotrophin (30x), aesculus hippocastanum, flos, alfalfa, alpha-lipoic ac, ambra, arg nit, avena sativa, bryonia, carboneum oxygenisatum, carpinus betulus, flos, dna, fumaricum acidum, gelsemium sempervirens, hepar sulphuris calcareum, hypothalamus, kali phosphoricum, lacticum acidum, lecithin, natrum muriaticum, oxalicum acidum, phosphoricum acidum, pituitarum posterium, sarcolacticum acidum, selenium metallicum, sepia, silicea, succinicum acidum and thyroidinum.· 1 maker
- aceticum acidum, adrenalinum, american ginseng, arnica montana, balsamum peruvianum, bos taurus pituitarum posterium, cherry plum flower, chininum arsenicosum, cinchona officinalis, clematis vitalba flower, damiana, european hornbeam flower, european olive flower, glycyrrhiza glabra, impatiens glandulifera flower, kali phosphoricum, lycopodium clavatum, magnesia phosphorica, phosphoricum acidum, phosphorus, pyrenees star of bethlehem, rockrose flower, selenium metallicum, thyroidinum· 1 maker
- acetylcholine chloride, taurine, adenosinum cyclophosphoricum, cerebrum (suis), diencephalon (suis), pineal gland (suis), thalamus opticus (suis), adrenalinum, dopamine hydrochloride, gaba (gamma-aminobutyric acid), norepinephrine (bitartrate), serotonin (hydrochloride), tyramine· 1 maker
Common questions
- Is Lidocaine hydrochloride,epinephrine bitartrate in shortage right now?
- Yes. FDA currently lists Lidocaine hydrochloride,epinephrine bitartrate in shortage, with the reason given as "demand increase for the drug". This page is rebuilt every morning from FDA's shortage database.
- Who makes Lidocaine hydrochloride,epinephrine bitartrate?
- 5 companies have marketed Lidocaine hydrochloride,epinephrine bitartrate in the last 30 days, according to the FDA NDC Directory. Every manufacturer and package is listed on this page.
Shortage reports for this molecule
- In shortage now — Xylocaine, Injection, .005 mg/1 mL; 15 mg/1 mL (NDC 63323-488-17)Oct 14, 2016
- In shortage now — Xylocaine, Injection, .005 mg/1 mL; 15 mg/1 mL (NDC 63323-488-37)Oct 14, 2016
- In shortage now — Xylocaine, Injection, .005 mg/1 mL; 20 mg/1 mL (NDC 63323-489-17)Oct 14, 2016
- In shortage now — Xylocaine, Injection, .005 mg/1 mL; 20 mg/1 mL (NDC 63323-489-27)Oct 14, 2016
- In shortage now — Xylocaine, Injection, .005 mg/1 mL; 5 mg/1 mL (NDC 63323-481-57)Oct 14, 2016
- In shortage now — Xylocaine, Injection, .01 mg/1 mL; 10 mg/1 mL (NDC 63323-482-17)Oct 14, 2016
All marketed products
Expand a strength to see its dosage forms, then package sizes, then each manufacturer and NDC. Click an NDC for its full detail page.