The short version
Only one company currently supplies this market — there is no backup if it stumbles.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Combigan
brimonidine tartrate, timolol maleate · BRIMONIDINE TARTRATE 2 mg/mL; TIMOLOL MALEATE 5 mg/mL · Solution/ Drops · Ophthalmic · Allergan, Inc.
NDC 00023-9211-03 · 1 BOTTLE, DROPPER in 1 CARTON / 2.5 mL in 1 BOTTLE, DROPPER · NDA · View full market →
Medicare Part D
All Part D pricing →Matched to CMS's representative package for this drug (NDC 00023-9211-05) — same generic, strength, and dosage form. CMS prices one NDC per drug concept, not every package.
ⓘ How this was built
Data sources
- CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method
Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
Plans pay at point of saleⓘ
$39.26per unit
middle half $38.70–$39.76 · 3,625 plans · Apr 1, 2026
Est. net of rebatesⓘ
$23.56–$29.44
brand drug — est. 25-40% rebate off the price at left
Coverage & restrictions
66%of plans cover it
tier 3 · prior auth 0% · step therapy 0% · qty limit 0%
*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.
NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
90-day shortage risk (model v2)
0.1%chance of a new FDA shortage posting for brimonidine tartrate and timolol maleate (other) in the next 90 days
OAI inspection at a producing facility (24 months) · sole-source market · 2 Class I/II recall(s) in 12 months
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
Regulatory
- Application
- NDA021398
- TE code
- AB
- Approval date
- Oct 30, 2007
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
- Class II · TerminatedMar 19, 2019Allergan Sales, LLC — cGMP Deviations
- Class III · TerminatedOct 19, 2017Allergan Sales, LLC — Failed Impurities/Degradation Specifications.
Manufacturers of brimonidine tartrate, timolol maleate (Solution/ Drops)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Allergan, Inc. | BRIMONIDINE TARTRATE 2 mg/mL; TIMOLOL MALEATE 5 mg/mL | Jul 15, 2026 | Sep 2, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "Combigan — NDC 00023-9211-03," retrieved September 3, 2026, https://drugdashboards.com/drug/00023921103.
Free to cite with attribution — see how the data is put together.