DrugDashboards

Estradiol

Estradiol · ESTRADIOL 10 ug/1 · Insert · Vaginal · Teva Pharmaceuticals USA, Inc.

NDC 00093-3223-08 · 8 BLISTER PACK in 1 CARTON / 1 APPLICATOR in 1 BLISTER PACK / 1 INSERT in 1 APPLICATOR · ANDA · View full market →

The short version

5 companies supply this market — a reasonable cushion if one runs into trouble. The generic price is down 19% over the past year, to $5.65 per unit. The brand (Imvexxy) runs $27.07 per unit 4.8× more. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$5.65per EAinvoice-surveyed acquisition cost · Aug 19, 2026
  • Part D plans paid (avg)$13.21per dosage unitgross, before rebates — matched by drug name · 2024
  • Part D point of sale (median)$7.65per unitnegotiated price across 5,377 plans — before rebates · Apr 1, 2026
  • Medicaid generic ceiling (FUL)$10.07per TABweighted avg manufacturer price $5.7561 · May 1, 2025178% of what pharmacies pay — higher than 86% of drugs with this benchmark

Medicare Part D

All Part D pricing →
ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$7.65per unit
middle half $5.28$10.80 · 5,377 plans · Apr 1, 2026
Est. net of rebates
≈ $7.65
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
98%of plans cover it
tier 4 · prior auth 0% · step therapy 0% · qty limit 19%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.

NADAC price per unit

$0$10.00$20.00Sep 2017Sep 2026$5.65
109 price points · per EA · dashed = manufacturer avg (WAMP)Source: CMS NADAC

Estimated fill cost

WAC per package, as filed
$155.18
Reported to Texas DSHS · 2026 annual filing · Teva Pharmaceuticals USA, Inc.

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicaid spend (2025)

$1.8M
19,610 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

5Low risk

Some pressure is visible, but not much — here’s everything the score found to count.

  • 5 active manufacturers+5

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for estradiol (other) in the next 90 days

sole-source market · 1 Class I/II recall(s) in 12 months

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Regulatory

Application
ANDA206388
TE code
AB
Approval date
Jul 21, 2017
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

  • Class II · TerminatedMar 19, 2018
    Teva Pharmaceuticals USADefective Container: This recall is being initiated due to product complaints regarding difficulty in dispensing the tablet from the applicator.

Manufacturers of Estradiol (Insert)

LabelerStrengthFirst seenLast seen
Bryant Ranch PrepackESTRADIOL 10 ug/1Jul 15, 2026Sep 3, 2026
Amneal Pharmaceuticals of New York LLCESTRADIOL 10 ug/1Jul 15, 2026Sep 2, 2026
Catalent Pharma Solutions LLCESTRADIOL 4 ug/1Jul 15, 2026Sep 2, 2026
Catalent Pharma Solutions LLCESTRADIOL 10 ug/1Jul 15, 2026Sep 2, 2026
Novo NordiskESTRADIOL 10 ug/1Jul 15, 2026Sep 2, 2026
Teva Pharmaceuticals USA, Inc.ESTRADIOL 10 ug/1Jul 15, 2026Sep 2, 2026
Mayne PharmaESTRADIOL 4 ug/1Jul 15, 2026Jul 29, 2026
Mayne PharmaESTRADIOL 10 ug/1Jul 15, 2026Jul 29, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Estradiol — NDC 00093-3223-08," retrieved September 3, 2026, https://drugdashboards.com/drug/00093322308.

Free to cite with attribution — see how the data is put together.