diphenhydramine hydrochloride and naproxen sodium
diphenhydramine hydrochloride and naproxen sodium · NAPROXEN SODIUM 220 mg/1; DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1 · Tablet, Coated · Bayer HealthCare LLC.
NDC 00280-0054-01 · 864211 TABLET, COATED in 1 DRUM · DRUG FOR FURTHER PROCESSING · View full market →
Bulk ingredient — not a finished product
This NDC is a raw material (drug for further processing) sold to drug manufacturers or compounders, not a product pharmacies dispense. Retail pricing, TE codes, fragility scores, and shortage reports don't apply to bulk listings — those attach to finished products made from this ingredient.
Medicare Part D
This is a bulk ingredient, not a dispensable product — it is a raw material sold to manufacturers and compounders, so no plan prices it.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
Regulatory
- Application
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- TE code
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- Approval date
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- Patents / exclusivity
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Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of diphenhydramine hydrochloride and naproxen sodium (Tablet, Coated)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Bayer HealthCare LLC. | NAPROXEN SODIUM 220 mg/1; DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1 | Aug 20, 2026 | Sep 3, 2026 |
| Bayer HealthCare LLC. | NAPROXEN SODIUM 25 mg/1; DIPHENHYDRAMINE HYDROCHLORIDE 220 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Bayer HealthCare LLC. | DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1; NAPROXEN SODIUM 220 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "diphenhydramine hydrochloride and naproxen sodium — NDC 00280-0054-01," retrieved September 3, 2026, https://drugdashboards.com/drug/00280005401.
Free to cite with attribution — see how the data is put together.