The short version
4 companies supply this market — a reasonable cushion if one runs into trouble.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Alka-Seltzer Hangover Relief
ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE · CAFFEINE 65 mg/1; ASPIRIN 500 mg/1 · Tablet, Effervescent · Oral · Bayer HealthCare LLC.
NDC 00280-0084-01 · 10 POUCH in 1 CARTON / 2 TABLET, EFFERVESCENT in 1 POUCH · OTC MONOGRAPH DRUG · View full market →
Medicare Part D
Medicare Part D does not cover over-the-counter drugs — by law it pays only for products requiring a prescription.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
90-day shortage risk (model v2)
0.1%chance of a new FDA shortage posting for anhydrous citric acid, aspirin, and sodium bicarbonate (oral solid) in the next 90 days
sole-source market
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
Regulatory
- Application
- M013
- TE code
- —
- Approval date
- —
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE (Tablet, Effervescent)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Bayer HealthCare LLC. | CAFFEINE 65 mg/1; ASPIRIN 500 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| JC World Bell Wholesale Co., Inc. | ANHYDROUS CITRIC ACID 1000 mg/1; ASPIRIN 325 mg/1; SODIUM BICARBONATE 1916 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| R J General Corporation | ASPIRIN 325 mg/1; SODIUM BICARBONATE 1916 mg/1; ANHYDROUS CITRIC ACID 1000 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Select Consumer Group | ANHYDROUS CITRIC ACID 1000 mg/1; ASPIRIN 325 mg/1; SODIUM BICARBONATE 1916 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Bayer HealthCare LLC. | ANHYDROUS CITRIC ACID 1000 mg/1; ASPIRIN 325 mg/1; SODIUM BICARBONATE 1916 mg/1 | Jul 15, 2026 | Aug 31, 2026 |
| Bayer HealthCare LLC. | CAFFEINE 500 mg/1; ASPIRIN 65 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| R J General Corporation | ASPIRIN 1000 mg/1; SODIUM BICARBONATE 325 mg/1; ANHYDROUS CITRIC ACID 1916 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Bayer HealthCare LLC. | ASPIRIN 500 mg/1; CAFFEINE 65 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| R J General Corporation | ANHYDROUS CITRIC ACID 1000 mg/1; ASPIRIN 325 mg/1; SODIUM BICARBONATE 1916 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "Alka-Seltzer Hangover Relief — NDC 00280-0084-01," retrieved September 3, 2026, https://drugdashboards.com/drug/00280008401.
Free to cite with attribution — see how the data is put together.