The short version
Just 3 companies supply this market — thin enough that a single exit would be felt immediately.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz
chlorpheniramine maleate, acetaminophen, phenylephrine hydrochloride, dextromethorphan hydrobromide · ACETAMINOPHEN 250 mg/1; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE HYDROCHLORIDE 5 mg/1 · Tablet, Effervescent · Oral · Bayer HealthCare LLC.
NDC 00280-0088-01 · 20 POUCH in 1 CARTON / 2 TABLET, EFFERVESCENT in 1 POUCH · OTC MONOGRAPH DRUG · View full market →
Medicare Part D
Medicare Part D does not cover over-the-counter drugs — by law it pays only for products requiring a prescription.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
Regulatory
- Application
- M012
- TE code
- —
- Approval date
- —
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of chlorpheniramine maleate, acetaminophen, phenylephrine hydrochloride, dextromethorphan hydrobromide (Tablet, Effervescent)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Bayer HealthCare LLC. | ACETAMINOPHEN 250 mg/1; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE HYDROCHLORIDE 5 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| Bayer HealthCare LLC. | DEXTROMETHORPHAN HYDROBROMIDE 10 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 250 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Navajo Manufacturing Company Inc. | DEXTROMETHORPHAN HYDROBROMIDE 10 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 250 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| R J General Corporation | PHENYLEPHRINE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 250 mg/1; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Bayer HealthCare LLC. | ACETAMINOPHEN 250 mg/1; DEXTROMETHORPHAN HYDROBROMIDE 2 mg/1; CHLORPHENIRAMINE MALEATE 10 mg/1; PHENYLEPHRINE HYDROCHLORIDE 5 mg/1 | Jul 22, 2026 | Aug 20, 2026 |
| Bayer HealthCare LLC. | DEXTROMETHORPHAN HYDROBROMIDE 250 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 5 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Navajo Manufacturing Company Inc. | DEXTROMETHORPHAN HYDROBROMIDE 250 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 5 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| R J General Corporation | PHENYLEPHRINE HYDROCHLORIDE 250 mg/1; ACETAMINOPHEN 2 mg/1; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/1; CHLORPHENIRAMINE MALEATE 5 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Bayer HealthCare LLC. | ACETAMINOPHEN 250 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/1; PHENYLEPHRINE HYDROCHLORIDE 5 mg/1 | Jul 15, 2026 | Jul 19, 2026 |
| Navajo Manufacturing Company Inc. | ACETAMINOPHEN 250 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/1; PHENYLEPHRINE HYDROCHLORIDE 5 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| R J General Corporation | ACETAMINOPHEN 250 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/1; PHENYLEPHRINE HYDROCHLORIDE 5 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "Alka-Seltzer Plus Severe Cold and Flu PowerFast Fizz — NDC 00280-0088-01," retrieved September 3, 2026, https://drugdashboards.com/drug/00280008801.
Free to cite with attribution — see how the data is put together.