The short version
16 companies supply this market — deep enough that no single failure threatens the supply.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Alka-Seltzer Plus Cold Orange Zest
Aspirin, Chlorpheniramine Maleate, Phenylephrine bitartrate · ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 · Tablet, Effervescent · Oral · Bayer HealthCare LLC.
NDC 00280-1510-20 · 10 POUCH in 1 CARTON / 2 TABLET, EFFERVESCENT in 1 POUCH · OTC MONOGRAPH DRUG · View full market →
Medicare Part D
Medicare Part D does not cover over-the-counter drugs — by law it pays only for products requiring a prescription.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
Is this a "specialty" drug?
There's no legal definition — it meets 1 of 6 public criteria. Why that matters →
- Part D specialty tier
- Costs ≥ $950/fill
- Biologic (BLA)
- Injectable / infused
- Orphan-drug exclusivity
- REMS program · Opioid Analgesic REMS Shared System REMS
Regulatory
- Application
- M012
- TE code
- —
- Approval date
- —
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of Aspirin, Chlorpheniramine Maleate, Phenylephrine bitartrate (Tablet, Effervescent)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Bayer HealthCare LLC. | PHENYLEPHRINE BITARTRATE 7 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; ASPIRIN 325 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| Bayer HealthCare LLC. | ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Jul 15, 2026 | Sep 3, 2026 |
| Bayer HealthCare LLC. | ASPIRIN 325 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Chain Drug Marketing Association | PHENYLEPHRINE BITARTRATE 7.8 mg/1; ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| CVS Pharmacy, Inc. | PHENYLEPHRINE BITARTRATE 7.8 mg/1; ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Discount Drug Mart | ASPIRIN 325 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Dolgencorp, Llc | PHENYLEPHRINE BITARTRATE 7.8 mg/1; ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Family Dollar Services, Inc. | CHLORPHENIRAMINE MALEATE 2 mg/1; ASPIRIN 325 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Good Sense | CHLORPHENIRAMINE MALEATE 2 mg/1; ASPIRIN 325 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| H. E. Butt Grocery Company | PHENYLEPHRINE BITARTRATE 7.8 mg/1; ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Kroger Company | ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Meijer Distribution Inc. | PHENYLEPHRINE BITARTRATE 7.8 mg/1; ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Tower Laboratories Ltd | ASPIRIN 325 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Tower Laboratories Ltd. | PHENYLEPHRINE BITARTRATE 7.8 mg/1; ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| United Natural Foods, Inc. dba UNFI | ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Valu Merchandiser Company | ASPIRIN 325 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Walgreens | ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Walmart | ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Meijer Distribution Inc. | ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Jul 15, 2026 | Aug 30, 2026 |
| Chain Drug Marketing Association | ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Jul 15, 2026 | Aug 28, 2026 |
| Bayer HealthCare LLC. | PHENYLEPHRINE BITARTRATE 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; ASPIRIN 7 mg/1 | Jul 22, 2026 | Aug 22, 2026 |
| Bayer HealthCare LLC. | ASPIRIN 325 mg/1; PHENYLEPHRINE BITARTRATE 2 mg/1; CHLORPHENIRAMINE MALEATE 7.8 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Chain Drug Marketing Association | PHENYLEPHRINE BITARTRATE 325 mg/1; ASPIRIN 2 mg/1; CHLORPHENIRAMINE MALEATE 7.8 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| CVS Pharmacy, Inc. | PHENYLEPHRINE BITARTRATE 325 mg/1; ASPIRIN 2 mg/1; CHLORPHENIRAMINE MALEATE 7.8 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Discount Drug Mart | ASPIRIN 325 mg/1; PHENYLEPHRINE BITARTRATE 2 mg/1; CHLORPHENIRAMINE MALEATE 7.8 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Dolgencorp, Llc | PHENYLEPHRINE BITARTRATE 325 mg/1; ASPIRIN 2 mg/1; CHLORPHENIRAMINE MALEATE 7.8 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Family Dollar Services, Inc. | CHLORPHENIRAMINE MALEATE 325 mg/1; ASPIRIN 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Good Sense | CHLORPHENIRAMINE MALEATE 325 mg/1; ASPIRIN 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| H. E. Butt Grocery Company | PHENYLEPHRINE BITARTRATE 325 mg/1; ASPIRIN 2 mg/1; CHLORPHENIRAMINE MALEATE 7.8 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Meijer Distribution Inc. | PHENYLEPHRINE BITARTRATE 325 mg/1; ASPIRIN 2 mg/1; CHLORPHENIRAMINE MALEATE 7.8 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Tower Laboratories Ltd | ASPIRIN 325 mg/1; PHENYLEPHRINE BITARTRATE 2 mg/1; CHLORPHENIRAMINE MALEATE 7.8 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Tower Laboratories Ltd. | PHENYLEPHRINE BITARTRATE 325 mg/1; ASPIRIN 2 mg/1; CHLORPHENIRAMINE MALEATE 7.8 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Valu Merchandiser Company | ASPIRIN 325 mg/1; PHENYLEPHRINE BITARTRATE 2 mg/1; CHLORPHENIRAMINE MALEATE 7.8 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Bayer HealthCare LLC. | ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE BITARTRATE 7 mg/1 | Jul 15, 2026 | Jul 19, 2026 |
| CVS Pharmacy, Inc. | ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Discount Drug Mart | ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Dolgencorp, Llc | ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Family Dollar Services, Inc. | ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Good Sense | ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| H. E. Butt Grocery Company | ASPIRIN 325 mg/1; CHLORPHENIRAMINE MALEATE 2 mg/1; PHENYLEPHRINE BITARTRATE 7.8 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "Alka-Seltzer Plus Cold Orange Zest — NDC 00280-1510-20," retrieved September 3, 2026, https://drugdashboards.com/drug/00280151020.
Free to cite with attribution — see how the data is put together.