The short version
4 companies supply this market — a reasonable cushion if one runs into trouble.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels
Acetaminophen, Dextromethorphan hydrobromide, Phenylephrine hydrochloride, Doxylamine succinate · Kit · Bayer HealthCare LLC.
NDC 00280-1650-16 · 1 KIT in 1 CARTON * 2 BLISTER PACK in 1 CARTON / 6 CAPSULE, LIQUID FILLED in 1 BLISTER PACK * 2 BLISTER PACK in 1 CARTON / 2 CAPSULE, LIQUID FILLED in 1 BLISTER PACK · OTC MONOGRAPH DRUG · View full market →
Medicare Part D
Medicare Part D does not cover over-the-counter drugs — by law it pays only for products requiring a prescription.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
90-day shortage risk (model v2)
0.1%chance of a new FDA shortage posting for acetaminophen, dextromethorphan hydrobromide, doxylamine succinate, phenylephrine hydrochloride (other) in the next 90 days
sole-source market
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
Is this a "specialty" drug?
There's no legal definition — it meets 1 of 6 public criteria. Why that matters →
- Part D specialty tier
- Costs ≥ $950/fill
- Biologic (BLA)
- Injectable / infused
- Orphan-drug exclusivity
- REMS program · Opioid Analgesic REMS Shared System REMS
Regulatory
- Application
- M012
- TE code
- —
- Approval date
- —
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of Acetaminophen, Dextromethorphan hydrobromide, Phenylephrine hydrochloride, Doxylamine succinate (Kit)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Bayer HealthCare LLC. | Jul 15, 2026 | Sep 3, 2026 | |
| Nuvicare Llc | Jul 15, 2026 | Sep 3, 2026 | |
| The Kroger Co. | Jul 15, 2026 | Sep 2, 2026 | |
| The Kroger Company | Jul 15, 2026 | Sep 2, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "Alka-Seltzer Plus Maximum Strength Day and Night Cold and Flu PowerMax Gels — NDC 00280-1650-16," retrieved September 3, 2026, https://drugdashboards.com/drug/00280165016.
Free to cite with attribution — see how the data is put together.