The short version
Only one company currently supplies this market — there is no backup if it stumbles.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
ALKA SELTZER COLD Cold Flu And Congestion Severe Fast Hot Liquid Day
ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, and PHENYLEPHRINE HYDROCHLORIDE · ACETAMINOPHEN 500 mg/1; DEXTROMETHORPHAN HYDROBROMIDE 20 mg/1; GUAIFENESIN 400 mg/1; PHENYLEPHRINE HYDROCHLORIDE 10 mg/1 · Powder, For Solution · Oral · Bayer HealthCare LLC.
NDC 00280-8273-06 · 6 PACKET in 1 CARTON / 1 POWDER, FOR SOLUTION in 1 PACKET · OTC MONOGRAPH DRUG · View full market →
Medicare Part D
Medicare Part D does not cover over-the-counter drugs — by law it pays only for products requiring a prescription.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
90-day shortage risk (model v2)
0.1%chance of a new FDA shortage posting for acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride (other) in the next 90 days
sole-source market
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
Is this a "specialty" drug?
There's no legal definition — it meets 1 of 6 public criteria. Why that matters →
- Part D specialty tier
- Costs ≥ $950/fill
- Biologic (BLA)
- Injectable / infused
- Orphan-drug exclusivity
- REMS program · Opioid Analgesic REMS Shared System REMS
Regulatory
- Application
- M012
- TE code
- —
- Approval date
- —
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, and PHENYLEPHRINE HYDROCHLORIDE (Powder, For Solution)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Bayer HealthCare LLC. | ACETAMINOPHEN 500 mg/1; DEXTROMETHORPHAN HYDROBROMIDE 20 mg/1; GUAIFENESIN 400 mg/1; PHENYLEPHRINE HYDROCHLORIDE 10 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "ALKA SELTZER COLD Cold Flu And Congestion Severe Fast Hot Liquid Day — NDC 00280-8273-06," retrieved September 3, 2026, https://drugdashboards.com/drug/00280827306.
Free to cite with attribution — see how the data is put together.