DrugDashboards

SymlinPen

pramlintide acetate · PRAMLINTIDE ACETATE 1000 ug/mL · Injection · Subcutaneous · AstraZeneca Pharmaceuticals LP

NDC 00310-6627-02 · 2 CARTRIDGE in 1 CARTON / 2.7 mL in 1 CARTRIDGE · NDA · View full market →

The short version

Only one company currently supplies this market — there is no backup if it stumbles. The price is up 12% over the past year, to $217.52 per mL. Put together: this is a fragile supply — if anything else goes wrong, there is very little slack to absorb it.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$217.52per MLinvoice-surveyed acquisition cost · Jun 18, 2025
  • Part D plans paid (avg)$218.40per dosage unitgross, before rebates — matched by drug name · 2024
  • Part D point of sale (median)$224.16per unitnegotiated price across 1,963 plans — before rebates · Oct 1, 2025
  • Federal ceiling (Big4)$917.49per package of 2X2.7MLASTRAZENECA PHARMACEUTICALS LP · Jan 1, 2026

Medicare Part D

All Part D pricing →
ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$224.16per unit
middle half $217.08$232.19 · 1,963 plans · Oct 1, 2025
Est. net of rebates
$134.50–$168.12
brand drug — est. 25-40% rebate off the price at left
Coverage & restrictions
36%of plans cover it
tier 5 · prior auth 62% · step therapy 4% · qty limit 71%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 8 quarters since 2024.

NADAC price per unit

$0$100.00$200.00$300.00Mar 2015Jun 2025$217.52
17 price points · per ML · last surveyed Invalid DateSource: CMS NADAC

Estimated fill cost

WAC per package, as filed
$1,230.16
Reported to Texas DSHS · 2025 annual filing · AstraZeneca

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicaid spend (2024)

$19,274
14 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

50High risk

Several kinds of pressure are visible at once — each line below is a condition that historically precedes supply trouble, and this market is stacking them.

  • 1 active manufacturer+30
  • sterile injectable+10
  • manufacturer plans to discontinue+10

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

Is this a "specialty" drug?

There's no legal definition — it meets 3 of 6 public criteria. Why that matters →

  • Part D specialty tier · median tier 5 across plans
  • Costs ≥ $950/fill · avg $2,133.73 per prescription
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program

Regulatory

Application
NDA021332
TE code
Approval date
Mar 16, 2005
Patents / exclusivity
None on file

Shortage history

  • Planned discontinuation SymlinPen® 120 , Injection, 1000 ug/1 mL (NDC 0310-6627-02)Oct 27, 2025
  • Planned discontinuation SymlinPen® 60 , Injection, 1000 ug/1 mL (NDC 0310-6615-02)Oct 27, 2025

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of pramlintide acetate (Injection)

LabelerStrengthFirst seenLast seen
AstraZeneca Pharmaceuticals LPPRAMLINTIDE ACETATE 1000 ug/mLJul 15, 2026Sep 3, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "SymlinPen — NDC 00310-6627-02," retrieved September 3, 2026, https://drugdashboards.com/drug/00310662702.

Free to cite with attribution — see how the data is put together.