DrugDashboards

ProSol

Valine, Lysine, Histidine, Isoleucine, Leucine, Phenylalanine, Threonine, Methionine, Tryptophan, Alanine, Glycine, Arginine, Proline, Glutamic Acid, Serine, Aspartic Acid and Tyrosine · VALINE 1.44 g/100mL; LYSINE ACETATE 1.35 g/100mL; HISTIDINE 1.18 g/100mL; ISOLEUCINE 1.08 g/100mL; LEUCINE 1.08 g/100mL; PHENYLALANINE 1 g/100mL; THREONINE 980 mg/100mL; METHIONINE 760 mg/100mL; TRYPTOPHAN 320 mg/100mL; ALANINE 2.76 g/100mL; GLYCINE 2.06 g/100mL; ARGININE 1.96 g/100mL; PROLINE 1.34 g/100mL; GLUTAMIC ACID 1.02 g/100mL; SERINE 1.02 g/100mL; ASPARTIC ACID 600 mg/100mL; TYROSINE 50 mg/100mL · Injection, Solution · Intravenous · Baxter Healthcare Corporation

NDC 00338-0499-06 · 2000 mL in 1 BAG · NDA · View full market →

The short version

Only one company currently supplies this market — there is no backup if it stumbles. It is in shortage right now.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Part D plans paid (avg)$0.1393per dosage unitgross, before rebates — matched by drug name · 2024
  • Part D point of sale (median)$0.0829per unitnegotiated price across 4,134 plans — before rebates · Apr 1, 2026
  • Federal contracts pay (FSS)$177.24per package of 6X2000MLBaxter Healthcare Corporation · Sep 17, 2025

Medicare Part D

All Part D pricing →
ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$0.0829per unit
middle half $0.0797$0.0833 · 4,134 plans · Apr 1, 2026
Est. net of rebates
$0.0497–$0.0622
brand drug — est. 25-40% rebate off the price at left
Coverage & restrictions
75%of plans cover it
tier 4 · prior auth 100% · step therapy 0% · qty limit 0%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.

NADAC price per unit

No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.

Estimated fill cost

WAC per package, as filed
$159.30
Reported to Texas DSHS · 2026 annual filing · Baxter Healthcare Corporation

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicaid spend (2025)

$875,151
7,060 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

Not scored — fragility is computed for NADAC-priced NDCs.

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

  • Part D specialty tier · median tier 4 across plans
  • Costs ≥ $950/fill · avg $166.93 per prescription
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program

Regulatory

Application
NDA020849
TE code
Approval date
Aug 26, 1998
Patents / exclusivity
None on file

Shortage history

  • In shortage now PROSOL 20% SULFITE FREE IN PLASTIC CONTAINER, Injection, 2.76 g/100 mL; 1.96 g/100 mL; 600 mg/100 mL; 1.02 g/100 mL; 2.06 g/100 mL; 1.18 g/100 mL; 1.08 g/100 mL; 1.08 g/100 mL; 1.35 g/100 mL; 760 mg/100 mL; 1 g/100 mL; 1.34 g/100 mL; 1.02 g/100 mL; 980 mg/100 mL; 320 mg/100 mL; 50 mg/100 mL; 1.44 g/100 mL (NDC 0338-0499-06)Dec 8, 2020
    month 69 — 3× the typical 20-month injectable shortage

Recalls (this NDC)

  • Class II · TerminatedAug 4, 2014
    Baxter Healthcare CorpPresence of Particulate Matter: identification of particulates in a retention sample that have been identified as a mixture of the amino acid leucine and inorganic material (containing iron, silicone and chlorine).

Manufacturers of Valine, Lysine, Histidine, Isoleucine, Leucine, Phenylalanine, Threonine, Methionine, Tryptophan, Alanine, Glycine, Arginine, Proline, Glutamic Acid, Serine, Aspartic Acid and Tyrosine (Injection, Solution)

LabelerStrengthFirst seenLast seen
Baxter Healthcare CorporationVALINE 1.44 g/100mL; LYSINE ACETATE 1.35 g/100mL; HISTIDINE 1.18 g/100mL; ISOLEUCINE 1.08 g/100mL; LEUCINE 1.08 g/100mL; PHENYLALANINE 1 g/100mL; THREONINE 980 mg/100mL; METHIONINE 760 mg/100mL; TRYPTOPHAN 320 mg/100mL; ALANINE 2.76 g/100mL; GLYCINE 2.06 g/100mL; ARGININE 1.96 g/100mL; PROLINE 1.34 g/100mL; GLUTAMIC ACID 1.02 g/100mL; SERINE 1.02 g/100mL; ASPARTIC ACID 600 mg/100mL; TYROSINE 50 mg/100mLAug 26, 2026Sep 2, 2026
Baxter Healthcare CorporationVALINE 2.76 g/100mL; LYSINE ACETATE 1.96 g/100mL; HISTIDINE 600 mg/100mL; ISOLEUCINE 1.02 g/100mL; LEUCINE 2.06 g/100mL; PHENYLALANINE 1.18 g/100mL; THREONINE 1.08 g/100mL; METHIONINE 1.08 g/100mL; TRYPTOPHAN 1.35 g/100mL; ALANINE 760 mg/100mL; GLYCINE 1 g/100mL; ARGININE 1.34 g/100mL; PROLINE 1.02 g/100mL; GLUTAMIC ACID 980 mg/100mL; SERINE 320 mg/100mL; ASPARTIC ACID 50 mg/100mL; TYROSINE 1.44 g/100mLJul 22, 2026Aug 19, 2026
Baxter Healthcare CorporationALANINE 2.76 g/100mL; ARGININE 1.96 g/100mL; ASPARTIC ACID 600 mg/100mL; GLUTAMIC ACID 1.02 g/100mL; GLYCINE 2.06 g/100mL; HISTIDINE 1.18 g/100mL; ISOLEUCINE 1.08 g/100mL; LEUCINE 1.08 g/100mL; LYSINE ACETATE 1.35 g/100mL; METHIONINE 760 mg/100mL; PHENYLALANINE 1 g/100mL; PROLINE 1.34 g/100mL; SERINE 1.02 g/100mL; THREONINE 980 mg/100mL; TRYPTOPHAN 320 mg/100mL; TYROSINE 50 mg/100mL; VALINE 1.44 g/100mLJul 15, 2026Jul 15, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "ProSol — NDC 00338-0499-06," retrieved September 3, 2026, https://drugdashboards.com/drug/00338049906.

Free to cite with attribution — see how the data is put together.