DrugDashboards

Metoprolol Tartrate and Hydrochlorothiazide

metoprolol tartrate and hydrochlorothiazide · METOPROLOL TARTRATE 100 mg/1; HYDROCHLOROTHIAZIDE 50 mg/1 · Tablet · Oral · Mylan Pharmaceuticals Inc.

NDC 00378-0445-01 · 100 TABLET in 1 BOTTLE, PLASTIC · ANDA · View full market →

The short version

5 companies supply this market — a reasonable cushion if one runs into trouble. The price has held steady around $1.54 per unit over the past year.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

Medicare Part D

All Part D pricing →
ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$1.37per unit
middle half $1.05$1.74 · 5,012 plans · Apr 1, 2026
Est. net of rebates
≈ $1.37
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
91%of plans cover it
tier 2 · prior auth 0% · step therapy 0% · qty limit 0%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.

NADAC price per unit

$0$1.00$2.00Mar 2013Apr 2014$1.54
3 price points · per · last surveyed Invalid DateSource: CMS NADAC

Estimated fill cost

WAC per package, as filed
$185.84
Reported to Texas DSHS · 2026 annual filing · Mylan Pharmaceuticals Inc.

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicaid spend (2024)

$2,736
37 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

Not scored — fragility is computed for NADAC-priced NDCs.

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for metoprolol tartrate and hydrochlorothiazide (oral solid) in the next 90 days

sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Regulatory

Application
ANDA076792
TE code
AB
Approval date
Aug 20, 2004
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of metoprolol tartrate and hydrochlorothiazide (Tablet)

LabelerStrengthFirst seenLast seen
Ajanta Pharma USA Inc.METOPROLOL TARTRATE 50 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 26, 2026Sep 2, 2026
Ajanta Pharma USA Inc.METOPROLOL TARTRATE 100 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 26, 2026Sep 2, 2026
Alembic Pharmaceuticals Inc.METOPROLOL TARTRATE 100 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 26, 2026Sep 2, 2026
Alembic Pharmaceuticals Inc.METOPROLOL TARTRATE 50 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 26, 2026Sep 2, 2026
Alembic Pharmaceuticals Inc.METOPROLOL TARTRATE 100 mg/1; HYDROCHLOROTHIAZIDE 50 mg/1Aug 26, 2026Sep 2, 2026
Alembic Pharmaceuticals LimitedMETOPROLOL TARTRATE 100 mg/1; HYDROCHLOROTHIAZIDE 50 mg/1Aug 26, 2026Sep 2, 2026
Alembic Pharmaceuticals LimitedMETOPROLOL TARTRATE 100 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 26, 2026Sep 2, 2026
Alembic Pharmaceuticals LimitedMETOPROLOL TARTRATE 50 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 26, 2026Sep 2, 2026
Mylan Pharmaceuticals Inc.METOPROLOL TARTRATE 50 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 26, 2026Sep 2, 2026
Mylan Pharmaceuticals Inc.METOPROLOL TARTRATE 100 mg/1; HYDROCHLOROTHIAZIDE 50 mg/1Aug 26, 2026Sep 2, 2026
Mylan Pharmaceuticals Inc.METOPROLOL TARTRATE 100 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 26, 2026Sep 2, 2026
Sun Pharmaceutical Industries, Inc.METOPROLOL TARTRATE 100 mg/1; HYDROCHLOROTHIAZIDE 50 mg/1Aug 26, 2026Sep 2, 2026
Sun Pharmaceutical Industries, Inc.METOPROLOL TARTRATE 50 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 26, 2026Sep 2, 2026
Sun Pharmaceutical Industries, Inc.METOPROLOL TARTRATE 100 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 26, 2026Sep 2, 2026
Ajanta Pharma USA Inc.METOPROLOL TARTRATE 25 mg/1; HYDROCHLOROTHIAZIDE 50 mg/1Jul 22, 2026Aug 19, 2026
Ajanta Pharma USA Inc.METOPROLOL TARTRATE 25 mg/1; HYDROCHLOROTHIAZIDE 100 mg/1Jul 22, 2026Aug 19, 2026
Alembic Pharmaceuticals Inc.METOPROLOL TARTRATE 25 mg/1; HYDROCHLOROTHIAZIDE 100 mg/1Jul 22, 2026Aug 19, 2026
Alembic Pharmaceuticals Inc.METOPROLOL TARTRATE 25 mg/1; HYDROCHLOROTHIAZIDE 50 mg/1Jul 22, 2026Aug 19, 2026
Alembic Pharmaceuticals Inc.METOPROLOL TARTRATE 50 mg/1; HYDROCHLOROTHIAZIDE 100 mg/1Jul 22, 2026Aug 19, 2026
Alembic Pharmaceuticals LimitedMETOPROLOL TARTRATE 25 mg/1; HYDROCHLOROTHIAZIDE 50 mg/1Jul 22, 2026Aug 19, 2026
Alembic Pharmaceuticals LimitedMETOPROLOL TARTRATE 25 mg/1; HYDROCHLOROTHIAZIDE 100 mg/1Jul 22, 2026Aug 19, 2026
Alembic Pharmaceuticals LimitedMETOPROLOL TARTRATE 50 mg/1; HYDROCHLOROTHIAZIDE 100 mg/1Jul 22, 2026Aug 19, 2026
Mylan Pharmaceuticals Inc.METOPROLOL TARTRATE 25 mg/1; HYDROCHLOROTHIAZIDE 50 mg/1Jul 22, 2026Aug 19, 2026
Mylan Pharmaceuticals Inc.METOPROLOL TARTRATE 25 mg/1; HYDROCHLOROTHIAZIDE 100 mg/1Jul 22, 2026Aug 19, 2026
Mylan Pharmaceuticals Inc.METOPROLOL TARTRATE 50 mg/1; HYDROCHLOROTHIAZIDE 100 mg/1Jul 22, 2026Aug 19, 2026
Sun Pharmaceutical Industries, Inc.METOPROLOL TARTRATE 25 mg/1; HYDROCHLOROTHIAZIDE 100 mg/1Jul 22, 2026Aug 19, 2026
Sun Pharmaceutical Industries, Inc.METOPROLOL TARTRATE 50 mg/1; HYDROCHLOROTHIAZIDE 100 mg/1Jul 22, 2026Aug 19, 2026
Sun Pharmaceutical Industries, Inc.METOPROLOL TARTRATE 25 mg/1; HYDROCHLOROTHIAZIDE 50 mg/1Jul 22, 2026Aug 19, 2026
Ajanta Pharma USA Inc.HYDROCHLOROTHIAZIDE 25 mg/1; METOPROLOL TARTRATE 50 mg/1Jul 15, 2026Jul 15, 2026
Ajanta Pharma USA Inc.HYDROCHLOROTHIAZIDE 25 mg/1; METOPROLOL TARTRATE 100 mg/1Jul 15, 2026Jul 15, 2026
Alembic Pharmaceuticals Inc.HYDROCHLOROTHIAZIDE 50 mg/1; METOPROLOL TARTRATE 100 mg/1Jul 15, 2026Jul 15, 2026
Alembic Pharmaceuticals Inc.HYDROCHLOROTHIAZIDE 25 mg/1; METOPROLOL TARTRATE 50 mg/1Jul 15, 2026Jul 15, 2026
Alembic Pharmaceuticals Inc.HYDROCHLOROTHIAZIDE 25 mg/1; METOPROLOL TARTRATE 100 mg/1Jul 15, 2026Jul 15, 2026
Alembic Pharmaceuticals LimitedHYDROCHLOROTHIAZIDE 50 mg/1; METOPROLOL TARTRATE 100 mg/1Jul 15, 2026Jul 15, 2026
Alembic Pharmaceuticals LimitedHYDROCHLOROTHIAZIDE 25 mg/1; METOPROLOL TARTRATE 100 mg/1Jul 15, 2026Jul 15, 2026
Alembic Pharmaceuticals LimitedHYDROCHLOROTHIAZIDE 25 mg/1; METOPROLOL TARTRATE 50 mg/1Jul 15, 2026Jul 15, 2026
Mylan Pharmaceuticals Inc.HYDROCHLOROTHIAZIDE 25 mg/1; METOPROLOL TARTRATE 50 mg/1Jul 15, 2026Jul 15, 2026
Mylan Pharmaceuticals Inc.HYDROCHLOROTHIAZIDE 25 mg/1; METOPROLOL TARTRATE 100 mg/1Jul 15, 2026Jul 15, 2026
Mylan Pharmaceuticals Inc.HYDROCHLOROTHIAZIDE 50 mg/1; METOPROLOL TARTRATE 100 mg/1Jul 15, 2026Jul 15, 2026
Sun Pharmaceutical Industries, Inc.HYDROCHLOROTHIAZIDE 25 mg/1; METOPROLOL TARTRATE 50 mg/1Jul 15, 2026Jul 15, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Metoprolol Tartrate and Hydrochlorothiazide — NDC 00378-0445-01," retrieved September 3, 2026, https://drugdashboards.com/drug/00378044501.

Free to cite with attribution — see how the data is put together.