DrugDashboards

Cyclosporine

cyclosporine · CYCLOSPORINE .5 mg/mL · Emulsion · Ophthalmic · Mylan Pharmaceuticals Inc.

NDC 00378-8760-91 · 12 POUCH in 1 CARTON / 5 VIAL, SINGLE-USE in 1 POUCH / .4 mL in 1 VIAL, SINGLE-USE · ANDA · View full market →

The short version

12 companies supply this market — deep enough that no single failure threatens the supply. The generic price has fallen 57% in a year, to $0.9240 per unit — and generics that get this cheap tend to get abandoned rather than defended. The brand (Restasis) runs $10.32 per unit 9.5× more. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$0.9240per EAinvoice-surveyed acquisition cost · Aug 19, 2026
  • Part D plans paid (avg)$9.34per dosage unitgross, before rebates — matched by drug name · 2024
  • Part D point of sale (median)$3.63per unitnegotiated price across 2,480 plans — before rebates · Apr 1, 2026

Medicare Part D

All Part D pricing →
ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$3.63per unit
middle half $2.78$5.87 · 2,480 plans · Apr 1, 2026
Est. net of rebates
≈ $3.63
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
45%of plans cover it
tier 3 · prior auth 0% · step therapy 0% · qty limit 86%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.

NADAC price per unit

$0$2.00$4.00$6.00Aug 2022Sep 2026$0.924
50 price points · per EASource: CMS NADAC

Estimated fill cost

WAC per package, as filed
$230.00
Reported to Texas DSHS · 2026 annual filing · Mylan Pharmaceuticals Inc.

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicaid spend (2025)

$774,987
4,543 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

15Low risk

Some pressure is visible, but not much — here’s everything the score found to count.

  • price down 56% year over year+15

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for cyclosporine (other) in the next 90 days

OAI inspection at a producing facility (24 months) · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Regulatory

Application
ANDA205894
TE code
AB
Approval date
Feb 2, 2022
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of cyclosporine (Emulsion)

LabelerStrengthFirst seenLast seen
Allergan, Inc.CYCLOSPORINE .5 mg/mLJul 15, 2026Sep 3, 2026
A-S Medication SolutionsCYCLOSPORINE .5 mg/mLJul 15, 2026Sep 2, 2026
Apotex CorpCYCLOSPORINE .5 mg/mLJul 15, 2026Sep 2, 2026
Devatis Inc.CYCLOSPORINE .5 mg/mLJul 15, 2026Sep 2, 2026
Harrow Eye, LLCCYCLOSPORINE 1 mg/mLJul 15, 2026Sep 2, 2026
Kvk-Tech, Inc.CYCLOSPORINE .5 mg/mLJul 15, 2026Sep 2, 2026
Lupin Pharmaceuticals, Inc.CYCLOSPORINE .5 mg/mLJul 15, 2026Sep 2, 2026
Mylan Pharmaceuticals Inc.CYCLOSPORINE .5 mg/mLJul 15, 2026Sep 2, 2026
Santen IncorporatedCYCLOSPORINE 1 mg/mLJul 15, 2026Sep 2, 2026
Saptalis Pharmaceuticals, LLCCYCLOSPORINE .5 mg/mLJul 15, 2026Sep 2, 2026
Teva Pharmaceuticals, Inc.CYCLOSPORINE .5 mg/mLJul 15, 2026Sep 2, 2026
Upsher-Smith Laboratories, LLCCYCLOSPORINE .5 mg/mLJul 15, 2026Sep 2, 2026
Amneal Pharmaceuticals NY LLCCYCLOSPORINE .5 mg/mLJul 15, 2026Jul 22, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Cyclosporine — NDC 00378-8760-91," retrieved September 3, 2026, https://drugdashboards.com/drug/00378876091.

Free to cite with attribution — see how the data is put together.