DrugDashboards

Piperacillin and Tazobactam

Piperacillin and Tazobactam · PIPERACILLIN SODIUM 12 g/60mL; TAZOBACTAM SODIUM 1.5 g/60mL · Injection, Powder, Lyophilized, For Solution · Intravenous; Parenteral · Hospira, Inc

NDC 00409-2999-14 · 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON / 60 mL in 1 VIAL, PHARMACY BULK PACKAGE · ANDA · View full market →

The short version

5 companies supply this market — a reasonable cushion if one runs into trouble. Historically, drugs in this position went on to a new shortage within 90 days about 0.4% of the time — roughly 3× the typical drug (0.1%).

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Medicare Part B pays (ASP+6%)$1.22per billing unit (1.125 GM)HCPCS J2543 · Jul 1, 2026
  • List price (WAC, as filed)$65.66per packagePfizer Inc. · Jan 1, 2024

Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.

Estimated fill cost

WAC per package, as filed
$65.66
Reported to Texas DSHS · 2026 annual filing · Pfizer Inc.

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicare Part B (ASP)

Payment limit per 1.125 GM
$1.218
HCPCS J2543 · Jul 1, 2026 quarter · typically ASP + 6%

Medicaid spend (2025)

$15,392
70 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

Not scored — fragility is computed for NADAC-priced NDCs.

90-day shortage risk (model v2)

0.4%chance of a new FDA shortage posting for piperacillin and tazobactam (injectable) in the next 90 days

sterile injectable · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is 3× that.

Backtested statistical model over the whole market, not this package alone. Model details →

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

  • Part D specialty tier
  • Costs ≥ $950/fill
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program

Regulatory

Application
ANDA203557
TE code
AP
Approval date
Oct 29, 2014
Patents / exclusivity
None on file

Shortage history

  • Planned discontinuation — Piperacillin and Tazobactam, Injection, 2.25 g vial (NDC 65219-434-20)Jan 20, 2026

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Piperacillin and Tazobactam (Injection, Powder, Lyophilized, For Solution)

LabelerStrengthFirst seenLast seen
Fresenius Kabi USA, LLCPIPERACILLIN SODIUM 4 g/20mL; TAZOBACTAM SODIUM .5 g/20mLJul 15, 2026Sep 3, 2026
Fresenius Kabi USA, LLCPIPERACILLIN SODIUM 3 g/15mL; TAZOBACTAM SODIUM .375 g/15mLJul 15, 2026Sep 3, 2026
Apotex Corp.TAZOBACTAM SODIUM 4.5 g/180mL; PIPERACILLIN SODIUM 36 g/180mLAug 26, 2026Sep 2, 2026
Hospira, IncPIPERACILLIN SODIUM 4 g/20mL; TAZOBACTAM SODIUM .5 g/20mLJul 15, 2026Sep 2, 2026
Hospira, IncPIPERACILLIN SODIUM 3 g/15mL; TAZOBACTAM SODIUM .375 g/15mLJul 15, 2026Sep 2, 2026
Hospira, IncPIPERACILLIN SODIUM 12 g/60mL; TAZOBACTAM SODIUM 1.5 g/60mLJul 15, 2026Sep 2, 2026
Sandoz IncPIPERACILLIN SODIUM 36 g/250mL; TAZOBACTAM SODIUM 4.5 g/250mLJul 15, 2026Sep 2, 2026
Shandong Anxin Pharmaceutical Co., Ltd.TAZOBACTAM SODIUM 4.5 g/180mL; PIPERACILLIN SODIUM 36 g/180mLAug 26, 2026Sep 2, 2026
Fresenius Kabi USA, LLCPIPERACILLIN SODIUM 2 g/10mL; TAZOBACTAM SODIUM .25 g/10mLJul 15, 2026Aug 31, 2026
Sandoz IncPIPERACILLIN SODIUM 4 g/20mL; TAZOBACTAM SODIUM .5 g/20mLJul 15, 2026Aug 29, 2026
Hospira, IncPIPERACILLIN SODIUM 2 g/10mL; TAZOBACTAM SODIUM .25 g/10mLJul 15, 2026Aug 28, 2026
Sandoz IncPIPERACILLIN SODIUM 2 g/10mL; TAZOBACTAM SODIUM .25 g/10mLJul 15, 2026Aug 28, 2026
Sandoz IncPIPERACILLIN SODIUM 3 g/15mL; TAZOBACTAM SODIUM .375 g/15mLJul 15, 2026Aug 28, 2026
Apotex Corp.TAZOBACTAM SODIUM 36 g/180mL; PIPERACILLIN SODIUM 4.5 g/180mLJul 22, 2026Aug 19, 2026
Shandong Anxin Pharmaceutical Co., Ltd.TAZOBACTAM SODIUM 36 g/180mL; PIPERACILLIN SODIUM 4.5 g/180mLJul 22, 2026Aug 19, 2026
Apotex Corp.PIPERACILLIN SODIUM 36 g/180mL; TAZOBACTAM SODIUM 4.5 g/180mLJul 15, 2026Jul 15, 2026
Shandong Anxin Pharmaceutical Co., Ltd.PIPERACILLIN SODIUM 36 g/180mL; TAZOBACTAM SODIUM 4.5 g/180mLJul 15, 2026Jul 15, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Piperacillin and Tazobactam — NDC 00409-2999-14," retrieved September 3, 2026, https://drugdashboards.com/drug/00409299914.

Free to cite with attribution — see how the data is put together.