DrugDashboards

Hydroxocobalamin

Hydroxocobalamin · HYDROXOCOBALAMIN ACETATE 1000 ug/mL · Injection, Solution · Intramuscular · Actavis Pharma, Inc.

NDC 00591-2888-30 · 1 VIAL, MULTI-DOSE in 1 CARTON / 30 mL in 1 VIAL, MULTI-DOSE · ANDA · View full market →

The short version

Only one company currently supplies this market — there is no backup if it stumbles. The price has held steady around $0.8144 per mL over the past year. It is in shortage right now — FDA lists the reason as “other. Put together: this is a fragile supply — if anything else goes wrong, there is very little slack to absorb it.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$0.8144per MLinvoice-surveyed acquisition cost · Mar 18, 2026
  • Medicare Part B pays (ASP+6%)$0.0070per billing unit (10 MCG)HCPCS J3425 · Jul 1, 2026

Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

$0$0.5$1.00Oct 2013Sep 2026$0.8144
26 price points · per ML · held since Invalid DateSource: CMS NADAC

Estimated fill cost

WAC per package, as filed
$25.00
Reported to Texas DSHS · 2025 annual filing · Actavis Pharma, Inc.

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicare Part B (ASP)

Payment limit per 10 MCG
$0.007
HCPCS J3425 · Jul 1, 2026 quarter · typically ASP + 6%

Medicaid spend (2025)

$19,262
1,007 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

65High risk

Several kinds of pressure are visible at once — each line below is a condition that historically precedes supply trouble, and this market is stacking them.

  • 1 active manufacturer+30
  • in shortage now+25
  • sterile injectable+10

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.4%chance of a new FDA shortage posting for hydroxocobalamin (injectable) in the next 90 days

sterile injectable · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is 3× that.

Backtested statistical model over the whole market, not this package alone. Model details →

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

  • Part D specialty tier
  • Costs ≥ $950/fill
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program

Regulatory

Application
ANDA085998
TE code
Approval date
Jan 1, 1982
Patents / exclusivity
None on file

Shortage history

  • In shortage now Hydroxocobalamin, Injection, 1000 MCG/ML, 30 ML Multi-Dose Vial (NDC 0591-2888-30)Nov 4, 2024
    Other
    month 22 of a typical 20 for injectable shortages · model puts 43% odds it resolves within 6 months

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Hydroxocobalamin (Injection, Solution)

LabelerStrengthFirst seenLast seen
Actavis Pharma, Inc.HYDROXOCOBALAMIN ACETATE 1000 ug/mLJul 15, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Hydroxocobalamin — NDC 00591-2888-30," retrieved September 3, 2026, https://drugdashboards.com/drug/00591288830.

Free to cite with attribution — see how the data is put together.