DrugDashboards

Diphenhydramine Hydrochloride

Diphenhydramine Hydrochloride · DIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1 · Capsule · Oral · Major Pharmaceuticals

NDC 00904-2056-61 · 10 BLISTER PACK in 1 BOX / 10 CAPSULE in 1 BLISTER PACK · OTC MONOGRAPH DRUG · View full market →

The short version

34 companies supply this market — deep enough that no single failure threatens the supply. The price is up 23% over the past year, to $0.0313 per unit. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$0.0313per EAinvoice-surveyed acquisition cost · Aug 19, 2026
  • Medicaid generic ceiling (FUL)$0.0535per CAPweighted avg manufacturer price $0.0306 · Feb 1, 2020171% of what pharmacies pay — higher than 81% of drugs with this benchmark

Medicare Part D

Medicare Part D does not cover over-the-counter drugs — by law it pays only for products requiring a prescription.

How Part D pricing works →

NADAC price per unit

$0$0.02$0.04Nov 2013Sep 2026$0.0313
152 price points · per EA · dashed = manufacturer avg (WAMP)Source: CMS NADAC

Estimated fill cost

#30 count
$0.94
#90 count
$2.82

Estimates: latest NADAC unit price × quantity. Pharmacy acquisition cost only — excludes dispensing fees, markup, and insurance terms.

Medicaid spend (2025)

$165,504
12,434 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

0● Low risk

Nothing here is signaling trouble: several manufacturers, no current shortage, no recent serious recalls, stable pricing. In drug supply, boring is the good outcome.

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for diphenhydramine hydrochloride (oral solid) in the next 90 days

sole-source market · price up 4% YoY

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Regulatory

Application
M012
TE code
—
Approval date
—
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

  • Class II · TerminatedMar 15, 2021
    Cardinal Health Inc. — CGMP Deviations: Intermittent exposure to temperature excursion during storage.

Manufacturers of Diphenhydramine Hydrochloride (Capsule)

LabelerStrengthFirst seenLast seen
Bioventure Healthcare - FZEDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 3, 2026
Patheon Softgels Inc.DIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 3, 2026
Walgreen CompanyDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 3, 2026
A-S Medication SolutionsDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Advance Pharmaceutical Inc.DIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Advance Pharmaceutical Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Amol Pharmaceuticals Private LimitedDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Bryant Ranch PrepackDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Cardinal Health 107, LLCDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Cardinal Health 110, Llc. Dba LeaderDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Aug 26, 2026Sep 2, 2026
Catalent Pharma Solutions, LLCDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Chain Drug Marketing AssociationDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Chain Drug Marketing Association, Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Contract Pharmacal Corp.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
CVS Pharmacy, Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Discount Drug MartDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Elysium Pharmaceuticals LimitedDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Epic Pharma, LLCDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Epic Pharma, LLCDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Harris TeeterDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
HF Acquisition Co LLC, DBA HealthFirstDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Hyvee IncDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Kroger CompanyDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
LEADER/ Cardinal Health 110, Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Major PharmaceuticalsDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Major PharmaceuticalsDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Marc Glassman, Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Patheon Softgels Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
PD-Rx Pharmaceuticals, Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Preferred Pharmaceuticals Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Retail Business Services , Llc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Richmond Pharmaceuticals Inc.DIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Richmond Pharmaceuticals Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Richmond Pharmaceuticals, Inc.DIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Richmond Pharmaceuticals, Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
St. Mary's Medical Park PharmacyDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Strive Pharmaceuticals IncDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
TopCo Associates LLCDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
United Natural Foods, Inc. dba UNFIDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Valu Merchandisers CompanyDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Diphenhydramine Hydrochloride — NDC 00904-2056-61," retrieved September 3, 2026, https://drugdashboards.com/drug/00904205661.

Free to cite with attribution — see how the data is put together.