Aminosyn-PF

ISOLEUCINE, LEUCINE, LYSINE ACETATE, METHIONINE, PHENYLALANINE, THREONINE, TRYPTOPHAN, VALINE, ALANINE, ARGININE, ASPARTIC ACID, GLUTAMIC ACID, GLYCINE, HISTIDINE, PROLINE, SERINE, TAURINE, and TYROSINE · ISOLEUCINE 534 mg/100mL; LEUCINE 831 mg/100mL; LYSINE ACETATE 475 mg/100mL; METHIONINE 125 mg/100mL; PHENYLALANINE 300 mg/100mL; THREONINE 360 mg/100mL; TRYPTOPHAN 125 mg/100mL; VALINE 452 mg/100mL; ALANINE 490 mg/100mL; ARGININE 861 mg/100mL; ASPARTIC ACID 370 mg/100mL; GLUTAMIC ACID 576 mg/100mL; GLYCINE 270 mg/100mL; HISTIDINE 220 mg/100mL; PROLINE 570 mg/100mL; SERINE 347 mg/100mL; TAURINE 50 mg/100mL; TYROSINE 44 mg/100mL · Injection, Solution · Intravenous · ICU Medical Inc.

NDC 00990-4178-03 · 12 BAG in 1 CASE / 500 mL in 1 BAG · NDA · View full market →

The short version

Only one company currently supplies this market — there is no backup if it stumbles. It is in shortage right now — FDA lists the reason as “shortage of an active ingredient”.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.

Estimated fill cost

WAC per package, as filed

$67.91

Reported to Texas DSHS · 2026 annual filing · Otsuka ICU Medical LLC

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Supply fragility

Not scored — fragility is computed for NADAC-priced NDCs.

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

Part D specialty tier
Costs ≥ $950/fill
Biologic (BLA)
Injectable / infused
Orphan-drug exclusivity
REMS program

Regulatory

Application: NDA019398
TE code: —
Approval date: Sep 6, 1985
Patents / exclusivity: None on file

Shortage history

In shortage now — Aminosyn-PF 10%, Injection, 0.1 (NDC 0990-4179-05)Dec 8, 2020
Shortage of an active ingredient
month 69 — 3× the typical 20-month injectable shortage
In shortage now — Aminosyn-PF 7%, Injection, 0.07 (NDC 0990-4178-03)Dec 8, 2020
Shortage of an active ingredient
month 69 — 3× the typical 20-month injectable shortage

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of ISOLEUCINE, LEUCINE, LYSINE ACETATE, METHIONINE, PHENYLALANINE, THREONINE, TRYPTOPHAN, VALINE, ALANINE, ARGININE, ASPARTIC ACID, GLUTAMIC ACID, GLYCINE, HISTIDINE, PROLINE, SERINE, TAURINE, and TYROSINE (Injection, Solution)

Labeler	Strength	First seen	Last seen
ICU Medical Inc.	ISOLEUCINE 534 mg/100mL; LEUCINE 831 mg/100mL; LYSINE ACETATE 475 mg/100mL; METHIONINE 125 mg/100mL; PHENYLALANINE 300 mg/100mL; THREONINE 360 mg/100mL; TRYPTOPHAN 125 mg/100mL; VALINE 452 mg/100mL; ALANINE 490 mg/100mL; ARGININE 861 mg/100mL; ASPARTIC ACID 370 mg/100mL; GLUTAMIC ACID 576 mg/100mL; GLYCINE 270 mg/100mL; HISTIDINE 220 mg/100mL; PROLINE 570 mg/100mL; SERINE 347 mg/100mL; TAURINE 50 mg/100mL; TYROSINE 44 mg/100mL	Aug 26, 2026	Sep 2, 2026
ICU Medical Inc.	ISOLEUCINE 760 mg/100mL; LEUCINE 1200 mg/100mL; LYSINE ACETATE 677 mg/100mL; METHIONINE 180 mg/100mL; PHENYLALANINE 427 mg/100mL; THREONINE 512 mg/100mL; TRYPTOPHAN 180 mg/100mL; VALINE 673 mg/100mL; ALANINE 698 mg/100mL; ARGININE 1227 mg/100mL; ASPARTIC ACID 527 mg/100mL; GLUTAMIC ACID 820 mg/100mL; GLYCINE 385 mg/100mL; HISTIDINE 312 mg/100mL; PROLINE 812 mg/100mL; SERINE 495 mg/100mL; TAURINE 70 mg/100mL; TYROSINE 44 mg/100mL	Aug 26, 2026	Sep 2, 2026
ICU Medical Inc.	ISOLEUCINE 490 mg/100mL; LEUCINE 861 mg/100mL; LYSINE ACETATE 370 mg/100mL; METHIONINE 576 mg/100mL; PHENYLALANINE 270 mg/100mL; THREONINE 220 mg/100mL; TRYPTOPHAN 534 mg/100mL; VALINE 831 mg/100mL; ALANINE 475 mg/100mL; ARGININE 125 mg/100mL; ASPARTIC ACID 300 mg/100mL; GLUTAMIC ACID 570 mg/100mL; GLYCINE 347 mg/100mL; HISTIDINE 50 mg/100mL; PROLINE 360 mg/100mL; SERINE 125 mg/100mL; TAURINE 44 mg/100mL; TYROSINE 452 mg/100mL	Jul 22, 2026	Aug 19, 2026
ICU Medical Inc.	ISOLEUCINE 698 mg/100mL; LEUCINE 1227 mg/100mL; LYSINE ACETATE 527 mg/100mL; METHIONINE 820 mg/100mL; PHENYLALANINE 385 mg/100mL; THREONINE 312 mg/100mL; TRYPTOPHAN 760 mg/100mL; VALINE 1200 mg/100mL; ALANINE 677 mg/100mL; ARGININE 180 mg/100mL; ASPARTIC ACID 427 mg/100mL; GLUTAMIC ACID 812 mg/100mL; GLYCINE 495 mg/100mL; HISTIDINE 70 mg/100mL; PROLINE 512 mg/100mL; SERINE 180 mg/100mL; TAURINE 44 mg/100mL; TYROSINE 673 mg/100mL	Jul 22, 2026	Aug 19, 2026
ICU Medical Inc.	ALANINE 490 mg/100mL; ARGININE 861 mg/100mL; ASPARTIC ACID 370 mg/100mL; GLUTAMIC ACID 576 mg/100mL; GLYCINE 270 mg/100mL; HISTIDINE 220 mg/100mL; ISOLEUCINE 534 mg/100mL; LEUCINE 831 mg/100mL; LYSINE ACETATE 475 mg/100mL; METHIONINE 125 mg/100mL; PHENYLALANINE 300 mg/100mL; PROLINE 570 mg/100mL; SERINE 347 mg/100mL; TAURINE 50 mg/100mL; THREONINE 360 mg/100mL; TRYPTOPHAN 125 mg/100mL; TYROSINE 44 mg/100mL; VALINE 452 mg/100mL	Jul 15, 2026	Jul 15, 2026
ICU Medical Inc.	ALANINE 698 mg/100mL; ARGININE 1227 mg/100mL; ASPARTIC ACID 527 mg/100mL; GLUTAMIC ACID 820 mg/100mL; GLYCINE 385 mg/100mL; HISTIDINE 312 mg/100mL; ISOLEUCINE 760 mg/100mL; LEUCINE 1200 mg/100mL; LYSINE ACETATE 677 mg/100mL; METHIONINE 180 mg/100mL; PHENYLALANINE 427 mg/100mL; PROLINE 812 mg/100mL; SERINE 495 mg/100mL; TAURINE 70 mg/100mL; THREONINE 512 mg/100mL; TRYPTOPHAN 180 mg/100mL; TYROSINE 44 mg/100mL; VALINE 673 mg/100mL	Jul 15, 2026	Jul 15, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Aminosyn-PF — NDC 00990-4178-03," retrieved September 3, 2026, https://drugdashboards.com/drug/00990417803.

Free to cite with attribution — see how the data is put together.