DrugDashboards

Cuprimine

penicillamine · PENICILLAMINE 250 mg/1 · Capsule · Oral · Bausch Health US, LLC

NDC 25010-0705-15 · 100 CAPSULE in 1 BOTTLE · NDA · View full market →

The short version

9 companies supply this market — a reasonable cushion if one runs into trouble. The price has jumped 373% in a year, to $255.85 per unit — sharp rises like this often mean supply is already tightening.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Part D plans paid (avg)$252.67per dosage unitgross, before rebates — matched by drug name · 2024
  • Part D point of sale (median)$263.39per unitnegotiated price across 16 plans — before rebates · Jul 1, 2024
  • Medicaid generic ceiling (FUL)$81.47per CAPweighted avg manufacturer price $46.5549 · Apr 1, 2025

Medicare Part D

All Part D pricing →
ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$263.39per unit
middle half $263.39$263.39 · 16 plans · Jul 1, 2024
Est. net of rebates
$158.03–$197.54
brand drug — est. 25-40% rebate off the price at left
Coverage & restrictions
of plans cover it

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 3 quarters since 2024.

NADAC price per unit

$0$100.00$200.00$300.00Dec 2013Jul 2015$255.85
6 price points · per · last surveyed Jul 1, 2015Source: CMS NADAC

Estimated fill cost

WAC per package, as filed
$26,188.64
Reported to Texas DSHS · 2026 annual filing · Bausch Health US, LLC

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Supply fragility

Not scored — fragility is computed for NADAC-priced NDCs.

Where it's made

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

  • Part D specialty tier
  • Costs ≥ $950/fill · avg $34,115.46 per prescription
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program

Regulatory

Application
NDA019853
TE code
AB
Approval date
Jan 1, 1982
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of penicillamine (Capsule)

LabelerStrengthFirst seenLast seen
Bausch Health US, LLCPENICILLAMINE 250 mg/1Jul 15, 2026Sep 2, 2026
Breckenridge Pharmaceutical, Inc.PENICILLAMINE 250 mg/1Jul 15, 2026Sep 2, 2026
Cycle Pharmaceuticals Ltd.PENICILLAMINE 250 mg/1Jul 15, 2026Sep 2, 2026
Granules Pharmaceuticals Inc.PENICILLAMINE 250 mg/1Jul 15, 2026Sep 2, 2026
Navinta LLCPENICILLAMINE 250 mg/1Jul 15, 2026Sep 2, 2026
Proficient Rx LPPENICILLAMINE 250 mg/1Jul 15, 2026Sep 2, 2026
Actavis Pharma, Inc.PENICILLAMINE 250 mg/1Jul 15, 2026Aug 28, 2026
Par Health USA, LLCPENICILLAMINE 250 mg/1Aug 7, 2026Aug 28, 2026
Endo USA, Inc.PENICILLAMINE 250 mg/1Jul 15, 2026Aug 5, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Cuprimine — NDC 25010-0705-15," retrieved September 3, 2026, https://drugdashboards.com/drug/25010070515.

Free to cite with attribution — see how the data is put together.