The short version
12 companies supply this market — deep enough that no single failure threatens the supply.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Hydroxyurea · HYDROXYUREA 500 mg/1 · Capsule · Oral · AvKARE
NDC 42291-0321-01 · 100 CAPSULE in 1 BOTTLE · ANDA · View full market →
12 companies supply this market — deep enough that no single failure threatens the supply.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.
Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
Matched to CMS's representative package for this drug (NDC 49884-0724-01) — same generic, strength, and dosage form. CMS prices one NDC per drug concept, not every package.
Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Manufacturer list price as filed — not what pharmacies actually pay after discounts.
Not scored — fragility is computed for NADAC-priced NDCs.
sole-source market
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
No FDA shortage reports for this drug or its presentations.
No enforcement reports list this package NDC.
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| American Health Packaging | HYDROXYUREA 500 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| AvKARE | HYDROXYUREA 500 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Coupler LLC | HYDROXYUREA 500 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Golden State Medical Supply, Inc. | HYDROXYUREA 500 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| H2-Pharma LLC | HYDROXYUREA 200 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| H2-Pharma LLC | HYDROXYUREA 300 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| H2-Pharma LLC | HYDROXYUREA 400 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| H2-Pharma LLC | HYDROXYUREA 500 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Leading Pharma, LLC | HYDROXYUREA 500 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Major Pharmaceuticals | HYDROXYUREA 500 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Par Health USA, LLC | HYDROXYUREA 500 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Qilu Pharmaceutical Co., Ltd. | HYDROXYUREA 500 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Somerset Therapeutics, LLC | HYDROXYUREA 500 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Teva Pharmaceuticals USA, Inc. | HYDROXYUREA 500 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Waylis Therapeutics LLC | HYDROXYUREA 400 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Waylis Therapeutics LLC | HYDROXYUREA 200 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Waylis Therapeutics LLC | HYDROXYUREA 500 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Waylis Therapeutics LLC | HYDROXYUREA 300 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
DrugDashboards, "Hydroxyurea — NDC 42291-0321-01," retrieved September 3, 2026, https://drugdashboards.com/drug/42291032101.
Free to cite with attribution — see how the data is put together.