DrugDashboards

Doxycycline Hyclate

Doxycycline Hyclate · DOXYCYCLINE HYCLATE 50 mg/1 · Tablet, Delayed Release · Oral · Solco Healthcare US LLC

NDC 43547-0462-12 · 120 TABLET, DELAYED RELEASE in 1 BOTTLE · ANDA · View full market →

The short version

8 companies supply this market — a reasonable cushion if one runs into trouble. The price has fallen 35% in a year, to $1.57 per unit — and generics that get this cheap tend to get abandoned rather than defended. One of its named manufacturing plants, Zhejiang Huahai Pharmaceutical Co., Ltd., failed FDA inspectionwithin the last two years — the agency’s most serious outcome. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$1.57per EAinvoice-surveyed acquisition cost · Apr 22, 2026
  • Part D plans paid (avg)$19.26per dosage unitgross, before rebates — matched by drug name · 2024
  • Medicaid generic ceiling (FUL)$7.12per TABweighted avg manufacturer price $3.6876 · Apr 1, 2022454% of what pharmacies pay — higher than 95% of drugs with this benchmark

Medicare Part D

All Part D pricing →

Matched to CMS's representative package for this drug (NDC 00591-4550-22) — same generic, strength, and dosage form. CMS prices one NDC per drug concept, not every package.

ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$5.86per unit
middle half $5.54$5.86 · 112 plans · Apr 1, 2026
Est. net of rebates
≈ $5.86
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
2%of plans cover it
tier 2 · prior auth 0% · step therapy 0% · qty limit 0%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.

NADAC price per unit

$0$2.50$5.00$7.50May 2021Sep 2026$1.57
17 price points · per EA · held since Invalid Date · dashed = manufacturer avg (WAMP)Source: CMS NADAC

Estimated fill cost

#30 count
$47.08
#90 count
$141.25

Estimates: latest NADAC unit price × quantity. Pharmacy acquisition cost only — excludes dispensing fees, markup, and insurance terms.

Medicaid spend (2024)

$2,342
14 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

8Low risk

Some pressure is visible, but not much — here’s everything the score found to count.

  • price down 35% year over year+8

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for doxycycline hyclate (oral solid) in the next 90 days

OAI inspection at a producing facility (24 months) · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Regulatory

Application
ANDA207494
TE code
AB
Approval date
Nov 15, 2016
Patents / exclusivity
None on file

Shortage history

  • Planned discontinuation Doxycycline Hyclate, Tablet, Delayed Release, 200 mg (NDC 0591-4575-60)Jul 30, 2026
  • Planned discontinuation Doxycycline Hyclate, Tablet, Delayed Release, 50 mg (NDC 0591-4550-22)Jul 30, 2026

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Doxycycline Hyclate (Tablet, Delayed Release)

LabelerStrengthFirst seenLast seen
Actavis Pharma, Inc.DOXYCYCLINE HYCLATE 200 mg/1Jul 15, 2026Sep 2, 2026
Actavis Pharma, Inc.DOXYCYCLINE HYCLATE 50 mg/1Jul 15, 2026Sep 2, 2026
Alembic Pharmaceuticals Inc.DOXYCYCLINE HYCLATE 100 mg/1Jul 15, 2026Sep 2, 2026
Alembic Pharmaceuticals Inc.DOXYCYCLINE HYCLATE 200 mg/1Jul 15, 2026Sep 2, 2026
Alembic Pharmaceuticals Inc.DOXYCYCLINE HYCLATE 150 mg/1Jul 15, 2026Sep 2, 2026
Alembic Pharmaceuticals Inc.DOXYCYCLINE HYCLATE 75 mg/1Jul 15, 2026Sep 2, 2026
Alembic Pharmaceuticals LimitedDOXYCYCLINE HYCLATE 200 mg/1Jul 15, 2026Sep 2, 2026
Alembic Pharmaceuticals LimitedDOXYCYCLINE HYCLATE 100 mg/1Jul 15, 2026Sep 2, 2026
Alembic Pharmaceuticals LimitedDOXYCYCLINE HYCLATE 150 mg/1Jul 15, 2026Sep 2, 2026
Alembic Pharmaceuticals LimitedDOXYCYCLINE HYCLATE 75 mg/1Jul 15, 2026Sep 2, 2026
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.DOXYCYCLINE HYCLATE 200 mg/1Jul 15, 2026Sep 2, 2026
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.DOXYCYCLINE HYCLATE 100 mg/1Jul 15, 2026Sep 2, 2026
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.DOXYCYCLINE HYCLATE 75 mg/1Jul 15, 2026Sep 2, 2026
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.DOXYCYCLINE HYCLATE 150 mg/1Jul 15, 2026Sep 2, 2026
Mayne Pharma Commercial LLCDOXYCYCLINE HYCLATE 60 mg/1Jul 15, 2026Sep 2, 2026
Mayne Pharma Commercial LLCDOXYCYCLINE HYCLATE 200 mg/1Jul 15, 2026Sep 2, 2026
Mayne Pharma International Pty Ltd.DOXYCYCLINE HYCLATE 60 mg/1Jul 15, 2026Sep 2, 2026
Solco Healthcare US LLCDOXYCYCLINE HYCLATE 150 mg/1Jul 15, 2026Sep 2, 2026
Solco Healthcare US LLCDOXYCYCLINE HYCLATE 200 mg/1Jul 15, 2026Sep 2, 2026
Solco Healthcare US LLCDOXYCYCLINE HYCLATE 50 mg/1Jul 15, 2026Sep 2, 2026
Sonoma Pharmaceuticals, Inc.DOXYCYCLINE HYCLATE 150 mg/1Jul 15, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Doxycycline Hyclate — NDC 43547-0462-12," retrieved September 3, 2026, https://drugdashboards.com/drug/43547046212.

Free to cite with attribution — see how the data is put together.