DrugDashboards

Extra Strength PM Pain Medicine

Acetaminophen, Diphenhydramine HCl · ACETAMINOPHEN 500 mg/1; DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1 · Tablet · Oral · Amerisource Bergen

NDC 46122-0799-69 · 1 BOTTLE in 1 CARTON / 50 TABLET in 1 BOTTLE · OTC MONOGRAPH DRUG · View full market →

The short version

7 companies supply this market — a reasonable cushion if one runs into trouble. The price has held steady around $0.0444 per unit over the past year. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

Medicare Part D

Medicare Part D does not cover over-the-counter drugs — by law it pays only for products requiring a prescription.

How Part D pricing works →

NADAC price per unit

$0$0.02$0.04$0.06May 2025Sep 2026$0.0444
17 price points · per EASource: CMS NADAC

Estimated fill cost

#30 count
$1.33
#90 count
$4.00

Estimates: latest NADAC unit price × quantity. Pharmacy acquisition cost only — excludes dispensing fees, markup, and insurance terms.

Supply fragility

0Low risk

Nothing here is signaling trouble: several manufacturers, no current shortage, no recent serious recalls, stable pricing. In drug supply, boring is the good outcome.

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for acetaminophen, diphenhydramine hcl (oral solid) in the next 90 days

sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

  • Part D specialty tier
  • Costs ≥ $950/fill
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program · Opioid Analgesic REMS Shared System REMS

Regulatory

Application
M013
TE code
Approval date
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Acetaminophen, Diphenhydramine HCl (Tablet)

LabelerStrengthFirst seenLast seen
Amerisource BergenACETAMINOPHEN 500 mg/1; DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Clarion Brands, LLCACETAMINOPHEN 500 mg/1; DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Dolgencorp, Inc.ACETAMINOPHEN 500 mg/1; DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Farmacias De Similares TX LLCDIPHENHYDRAMINE HCL 25 mg/1; ACETAMINOPHEN 500 mg/1Aug 26, 2026Sep 2, 2026
Geri-Care Pharmaceutical CorpACETAMINOPHEN 500 mg/1; DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Ingles Markets, Inc.ACETAMINOPHEN 500 mg/1; DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
New World Imports, IncACETAMINOPHEN 500 mg/1; DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Aug 31, 2026
Farmacias De Similares TX LLCDIPHENHYDRAMINE HCL 500 mg/1; ACETAMINOPHEN 25 mg/1Jul 22, 2026Aug 19, 2026
Farmacias De Similares TX LLCACETAMINOPHEN 500 mg/1; DIPHENHYDRAMINE HCL 25 mg/1Jul 15, 2026Jul 15, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Extra Strength PM Pain Medicine — NDC 46122-0799-69," retrieved September 3, 2026, https://drugdashboards.com/drug/46122079969.

Free to cite with attribution — see how the data is put together.