The short version
12 companies supply this market — deep enough that no single failure threatens the supply.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Desvenlafaxine Succinate · DESVENLAFAXINE SUCCINATE 100 mg/1 · Tablet, Extended Release · Oral · Alembic Pharmaceuticals Limited
NDC 46708-0541-10 · 100 TABLET, EXTENDED RELEASE in 1 CARTON · ANDA · View full market →
12 companies supply this market — deep enough that no single failure threatens the supply.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Matched to CMS's representative package for this drug (NDC 00008-1222-30) — same generic, strength, and dosage form. CMS prices one NDC per drug concept, not every package.
Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Not scored — fragility is computed for NADAC-priced NDCs.
sole-source market
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
Establishments this product's FDA label declares, located via FDA registration data. How we built this →
No FDA shortage reports for this drug or its presentations.
No enforcement reports list this package NDC.
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| A-S Medication Solutions | DESVENLAFAXINE SUCCINATE 50 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| A-S Medication Solutions | DESVENLAFAXINE SUCCINATE 25 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Alembic Pharmaceuticals Limited | DESVENLAFAXINE SUCCINATE 50 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Alembic Pharmaceuticals Limited | DESVENLAFAXINE SUCCINATE 100 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Alembic Pharmaceuticals Limited | DESVENLAFAXINE SUCCINATE 25 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Breckenridge Pharmaceutical, Inc | DESVENLAFAXINE SUCCINATE 100 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Breckenridge Pharmaceutical, Inc | DESVENLAFAXINE SUCCINATE 25 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Breckenridge Pharmaceutical, Inc | DESVENLAFAXINE SUCCINATE 50 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Bryant Ranch Prepack | DESVENLAFAXINE SUCCINATE 100 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Bryant Ranch Prepack | DESVENLAFAXINE SUCCINATE 25 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Bryant Ranch Prepack | DESVENLAFAXINE SUCCINATE 50 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Coupler LLC | DESVENLAFAXINE SUCCINATE 100 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Direct Rx | DESVENLAFAXINE SUCCINATE 50 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Macleods Pharmaceuticals Limited | DESVENLAFAXINE SUCCINATE 100 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Macleods Pharmaceuticals Limited | DESVENLAFAXINE SUCCINATE 50 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Pfizer Ireland Pharmaceuticals Unlimited Company | DESVENLAFAXINE SUCCINATE 100 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Pfizer Ireland Pharmaceuticals Unlimited Company | DESVENLAFAXINE SUCCINATE 50 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Pfizer Ireland Pharmaceuticals Unlimited Company | DESVENLAFAXINE SUCCINATE 25 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Preferred Pharmaceutical, Inc. | DESVENLAFAXINE SUCCINATE 50 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Preferred Pharmaceuticals Inc. | DESVENLAFAXINE SUCCINATE 100 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Proficient Rx LP | DESVENLAFAXINE SUCCINATE 100 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc. | DESVENLAFAXINE SUCCINATE 25 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc. | DESVENLAFAXINE SUCCINATE 100 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc. | DESVENLAFAXINE SUCCINATE 50 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
DrugDashboards, "Desvenlafaxine — NDC 46708-0541-10," retrieved September 3, 2026, https://drugdashboards.com/drug/46708054110.
Free to cite with attribution — see how the data is put together.