DrugDashboards

Topamax

topiramate · TOPIRAMATE 15 mg/1 · Capsule, Coated Pellets · Oral · Janssen Pharmaceuticals, Inc.

NDC 50458-0647-65 · 60 CAPSULE, COATED PELLETS in 1 BOTTLE · NDA · View full market →

The short version

5 companies supply this market — a reasonable cushion if one runs into trouble. The price is up 10% over the past year, to $4.39 per unit.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Part D plans paid (avg)$15.99per dosage unitgross, before rebates — matched by drug name · 2024
  • Part D point of sale (median)$5.83per unitnegotiated price across 2 plans — before rebates · Jul 1, 2024
  • Federal ceiling (Big4)$4.72per unitJohnson & Johnson Health Care Systems, Inc. obo Janssen Pharmaceuticals,Inc · Jan 1, 2026
  • Medicaid generic ceiling (FUL)$0.4281per CAPweighted avg manufacturer price $0.2446 · Aug 1, 2026

Medicare Part D

All Part D pricing →
ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$5.83per unit
middle half $5.83$5.83 · 2 plans · Jul 1, 2024
Est. net of rebates
$3.50–$4.37
brand drug — est. 25-40% rebate off the price at left
Coverage & restrictions
of plans cover it

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 3 quarters since 2024.

NADAC price per unit

$0$2.00$4.00$6.00Jul 2013Jan 2016$4.39
4 price points · per · last surveyed Invalid DateSource: CMS NADAC

Estimated fill cost

WAC per package, as filed
$6.32
Reported to Texas DSHS · 2026 annual filing · Johnson & Johnson Health Care Systems Inc

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicaid spend (2023)

$15,751
25 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

Not scored — fragility is computed for NADAC-priced NDCs.

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for topiramate (oral solid) in the next 90 days

OAI inspection at a producing facility (24 months) · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

  • Part D specialty tier
  • Costs ≥ $950/fill · avg $1,922.19 per prescription
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program

Regulatory

Application
NDA020844
TE code
AB
Approval date
Oct 26, 1998
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of topiramate (Capsule, Coated Pellets)

LabelerStrengthFirst seenLast seen
Glenmark Pharmaceuticals Inc., USATOPIRAMATE 15 mg/1Jul 15, 2026Sep 2, 2026
Glenmark Pharmaceuticals Inc., USATOPIRAMATE 25 mg/1Jul 15, 2026Sep 2, 2026
Janssen Pharmaceuticals, Inc.TOPIRAMATE 25 mg/1Jul 15, 2026Sep 2, 2026
Janssen Pharmaceuticals, Inc.TOPIRAMATE 15 mg/1Jul 15, 2026Sep 2, 2026
Remedyrepack Inc.TOPIRAMATE 25 mg/1Jul 15, 2026Sep 2, 2026
Zydus Lifesciences LimitedTOPIRAMATE 15 mg/1Jul 15, 2026Sep 2, 2026
Zydus Lifesciences LimitedTOPIRAMATE 25 mg/1Jul 15, 2026Sep 2, 2026
Zydus Lifesciences LimitedTOPIRAMATE 50 mg/1Jul 15, 2026Sep 2, 2026
Zydus Pharmaceuticals USA Inc.TOPIRAMATE 25 mg/1Jul 15, 2026Sep 2, 2026
Zydus Pharmaceuticals USA Inc.TOPIRAMATE 50 mg/1Jul 15, 2026Sep 2, 2026
Zydus Pharmaceuticals USA Inc.TOPIRAMATE 15 mg/1Jul 15, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Topamax — NDC 50458-0647-65," retrieved September 3, 2026, https://drugdashboards.com/drug/50458064765.

Free to cite with attribution — see how the data is put together.