The short version
12 companies supply this market — deep enough that no single failure threatens the supply.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Multi-Symptom PMS Relief
Acetaminophen, Pamabrom, Pyrilamine maleate · ACETAMINOPHEN 500 mg/1; PAMABROM 25 mg/1; PYRILAMINE MALEATE 15 mg/1 · Tablet, Film Coated · Oral · Cvs Woonsocket Prescription Center, Incorporated
NDC 51316-0679-27 · 1 BOTTLE, PLASTIC in 1 CARTON / 32 TABLET, FILM COATED in 1 BOTTLE, PLASTIC · OTC MONOGRAPH DRUG · View full market →
Medicare Part D
Medicare Part D does not cover over-the-counter drugs — by law it pays only for products requiring a prescription.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
90-day shortage risk (model v2)
0.1%chance of a new FDA shortage posting for acetaminophen, pamabrom, pyrilamine maleate (oral solid) in the next 90 days
sole-source market · price up 2% YoY
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
Is this a "specialty" drug?
There's no legal definition — it meets 1 of 6 public criteria. Why that matters →
- Part D specialty tier
- Costs ≥ $950/fill
- Biologic (BLA)
- Injectable / infused
- Orphan-drug exclusivity
- REMS program · Opioid Analgesic REMS Shared System REMS
Regulatory
- Application
- M027
- TE code
- —
- Approval date
- —
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of Acetaminophen, Pamabrom, Pyrilamine maleate (Tablet, Film Coated)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Army And Air Force Exchange Service | ACETAMINOPHEN 500 mg/1; PAMABROM 25 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Cardinal Health 110, LLC. DBA Leader | ACETAMINOPHEN 500 mg/1; PAMABROM 25 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Chain Drug Marketing Association, Inc. | ACETAMINOPHEN 500 mg/1; PAMABROM 25 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| CVS Pharmacy | ACETAMINOPHEN 500 mg/1; PAMABROM 25 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Cvs Woonsocket Prescription Center, Incorporated | ACETAMINOPHEN 500 mg/1; PAMABROM 25 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Dolgencorp, Llc | ACETAMINOPHEN 500 mg/1; PAMABROM 25 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Family Dollar Services Inc | ACETAMINOPHEN 500 mg/1; PAMABROM 25 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| L.N.K. International, Inc. | ACETAMINOPHEN 500 mg/1; PAMABROM 25 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Rite Aid Corporation | ACETAMINOPHEN 500 mg/1; PAMABROM 25 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Thompson Safety | ACETAMINOPHEN 500 mg/1; PAMABROM 25 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Topco Associates, LLC | ACETAMINOPHEN 500 mg/1; PAMABROM 25 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Unifirst First Aid Corporation | PYRILAMINE MALEATE 15 mg/1; ACETAMINOPHEN 500 mg/1; PAMABROM 25 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Unifirst First Aid Corporation | PYRILAMINE MALEATE 500 mg/1; ACETAMINOPHEN 25 mg/1; PAMABROM 15 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Unifirst First Aid Corporation | ACETAMINOPHEN 500 mg/1; PAMABROM 25 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "Multi-Symptom PMS Relief — NDC 51316-0679-27," retrieved September 3, 2026, https://drugdashboards.com/drug/51316067927.
Free to cite with attribution — see how the data is put together.