The short version
16 companies supply this market — deep enough that no single failure threatens the supply.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Combogesic
ACETAMINOPHEN and IBUPROFEN · ACETAMINOPHEN 325 mg/1; IBUPROFEN 97.5 mg/1 · Tablet, Film Coated · Oral · Preferred Pharmaceuticals Inc.
NDC 68788-4009-01 · 120 TABLET, FILM COATED in 1 BOTTLE, PLASTIC · NDA · View full market →
Medicare Part D
No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
90-day shortage risk (model v2)
0.1%chance of a new FDA shortage posting for acetaminophen and ibuprofen (oral solid) in the next 90 days
price up 19% YoY · sole-source market
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
Where it's made
- Preferred Pharmaceuticals Inc.United Statesrepack
Establishments this product's FDA label declares, located via FDA registration data. How we built this →
Is this a "specialty" drug?
There's no legal definition — it meets 1 of 6 public criteria. Why that matters →
- Part D specialty tier
- Costs ≥ $950/fill
- Biologic (BLA)
- Injectable / infused
- Orphan-drug exclusivity
- REMS program · Opioid Analgesic REMS Shared System REMS
Regulatory
- Application
- NDA209471
- TE code
- —
- Approval date
- Mar 1, 2023
- Patents / exclusivity
- 2 patents, 1 exclusivities
| Type | Number / code | Expires |
|---|---|---|
| exclusivity | NP | Mar 1, 2026 |
| patent | 11534407 | Feb 27, 2039 |
| patent | 11197830 | Feb 27, 2039 |
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of ACETAMINOPHEN and IBUPROFEN (Tablet, Film Coated)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Aurohealth LLC | ACETAMINOPHEN 250 mg/1; IBUPROFEN 125 mg/1 | Jul 15, 2026 | Sep 3, 2026 |
| Bionpharma Inc. | IBUPROFEN 125 mg/1; ACETAMINOPHEN 250 mg/1 | Aug 20, 2026 | Sep 3, 2026 |
| AFT Pharmaceuticals US, Inc. | ACETAMINOPHEN 325 mg/1; IBUPROFEN 97.5 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Amerisource Bergen | IBUPROFEN 125 mg/1; ACETAMINOPHEN 250 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Bionpharma Inc. | IBUPROFEN 125 mg/1; ACETAMINOPHEN 250 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Bryant Ranch Prepack | ACETAMINOPHEN 325 mg/1; IBUPROFEN 97.5 mg/1 | Aug 5, 2026 | Sep 2, 2026 |
| CVS Pharmacy | IBUPROFEN 125 mg/1; ACETAMINOPHEN 250 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Discount Drug Mart, Inc. | IBUPROFEN 125 mg/1; ACETAMINOPHEN 250 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Dr. Reddy's Labortories Inc | IBUPROFEN 125 mg/1; ACETAMINOPHEN 250 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Hikma Pharmaceuticals USA Inc | ACETAMINOPHEN 325 mg/1; IBUPROFEN 97.5 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Kenvue Brands LLC | IBUPROFEN 125 mg/1; ACETAMINOPHEN 250 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Meijer Distribution Inc | IBUPROFEN 125 mg/1; ACETAMINOPHEN 250 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Walgreen Company | IBUPROFEN 125 mg/1; ACETAMINOPHEN 250 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Aurobindo Pharma Limited | ACETAMINOPHEN 250 mg/1; IBUPROFEN 125 mg/1 | Jul 15, 2026 | Aug 31, 2026 |
| Chain Drug Marketing Association Inc. | IBUPROFEN 125 mg/1; ACETAMINOPHEN 250 mg/1 | Aug 26, 2026 | Aug 31, 2026 |
| Preferred Pharmaceuticals Inc. | ACETAMINOPHEN 325 mg/1; IBUPROFEN 97.5 mg/1 | Jul 15, 2026 | Aug 31, 2026 |
| Chain Drug Marketing Association Inc. | IBUPROFEN 250 mg/1; ACETAMINOPHEN 125 mg/1 | Jul 22, 2026 | Aug 22, 2026 |
| Amerisource Bergen | IBUPROFEN 250 mg/1; ACETAMINOPHEN 125 mg/1 | Jul 22, 2026 | Aug 21, 2026 |
| Bionpharma Inc. | IBUPROFEN 250 mg/1; ACETAMINOPHEN 125 mg/1 | Jul 22, 2026 | Aug 21, 2026 |
| CVS Pharmacy | IBUPROFEN 250 mg/1; ACETAMINOPHEN 125 mg/1 | Jul 23, 2026 | Aug 20, 2026 |
| Bionpharma Inc. | IBUPROFEN 250 mg/1; ACETAMINOPHEN 125 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Discount Drug Mart, Inc. | IBUPROFEN 250 mg/1; ACETAMINOPHEN 125 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Dr. Reddy's Labortories Inc | IBUPROFEN 250 mg/1; ACETAMINOPHEN 125 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Kenvue Brands LLC | IBUPROFEN 250 mg/1; ACETAMINOPHEN 125 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Meijer Distribution Inc | IBUPROFEN 250 mg/1; ACETAMINOPHEN 125 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Walgreen Company | IBUPROFEN 250 mg/1; ACETAMINOPHEN 125 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Chain Drug Marketing Association Inc. | ACETAMINOPHEN 250 mg/1; IBUPROFEN 125 mg/1 | Jul 15, 2026 | Jul 19, 2026 |
| Amerisource Bergen | ACETAMINOPHEN 250 mg/1; IBUPROFEN 125 mg/1 | Jul 15, 2026 | Jul 18, 2026 |
| Bionpharma Inc. | ACETAMINOPHEN 250 mg/1; IBUPROFEN 125 mg/1 | Jul 15, 2026 | Jul 18, 2026 |
| Bionpharma Inc. | ACETAMINOPHEN 250 mg/1; IBUPROFEN 125 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Discount Drug Mart, Inc. | ACETAMINOPHEN 250 mg/1; IBUPROFEN 125 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Dr. Reddy's Labortories Inc | ACETAMINOPHEN 250 mg/1; IBUPROFEN 125 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Kenvue Brands LLC | ACETAMINOPHEN 250 mg/1; IBUPROFEN 125 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Meijer Distribution Inc | ACETAMINOPHEN 250 mg/1; IBUPROFEN 125 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Walgreen Company | ACETAMINOPHEN 250 mg/1; IBUPROFEN 125 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "Combogesic — NDC 68788-4009-01," retrieved September 3, 2026, https://drugdashboards.com/drug/68788400901.
Free to cite with attribution — see how the data is put together.