DrugDashboards

memantine hydrochloride and donepezil hydrochloride

memantine hydrochloride and donepezil hydrochloride · MEMANTINE HYDROCHLORIDE 14 mg/1; DONEPEZIL HYDROCHLORIDE 10 mg/1 · Capsule, Extended Release · Oral · Vitruvias Therapeutics, Inc.

NDC 69680-0183-30 · 30 CAPSULE, EXTENDED RELEASE in 1 BOTTLE · ANDA · View full market →

The short version

Only one company currently supplies this market — there is no backup if it stumbles. The price has fallen 55% in a year, to $7.33 per unit — and generics that get this cheap tend to get abandoned rather than defended. Put together: worth watching — several of the pressures that precede supply trouble are present at once.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$7.33per EAinvoice-surveyed acquisition cost · Aug 19, 2026
  • Medicaid generic ceiling (FUL)$15.38per CAPweighted avg manufacturer price $8.7913 · Aug 1, 2026210% of what pharmacies pay — higher than 86% of drugs with this benchmark

Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

$0$10.00$20.00Sep 2025Sep 2026$7.33
13 price points · per EA · dashed = manufacturer avg (WAMP)Source: CMS NADAC

Estimated fill cost

#30 count
$220.04
#90 count
$660.13

Estimates: latest NADAC unit price × quantity. Pharmacy acquisition cost only — excludes dispensing fees, markup, and insurance terms.

Supply fragility

30Elevated risk

The score is counting real pressure here. One of these alone is routine; it’s the combination that makes this market worth watching.

  • 1 active manufacturer+30

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for memantine hydrochloride and donepezil hydrochloride (oral solid) in the next 90 days

sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Regulatory

Application
ANDA216901
TE code
AB
Approval date
Jul 15, 2025
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of memantine hydrochloride and donepezil hydrochloride (Capsule, Extended Release)

LabelerStrengthFirst seenLast seen
Vitruvias Therapeutics, Inc.MEMANTINE HYDROCHLORIDE 14 mg/1; DONEPEZIL HYDROCHLORIDE 10 mg/1Aug 26, 2026Sep 2, 2026
Vitruvias Therapeutics, Inc.MEMANTINE HYDROCHLORIDE 28 mg/1; DONEPEZIL HYDROCHLORIDE 10 mg/1Aug 26, 2026Sep 2, 2026
Vitruvias Therapeutics, Inc.MEMANTINE HYDROCHLORIDE 10 mg/1; DONEPEZIL HYDROCHLORIDE 14 mg/1Jul 22, 2026Aug 19, 2026
Vitruvias Therapeutics, Inc.MEMANTINE HYDROCHLORIDE 10 mg/1; DONEPEZIL HYDROCHLORIDE 28 mg/1Jul 22, 2026Aug 19, 2026
Vitruvias Therapeutics, Inc.DONEPEZIL HYDROCHLORIDE 10 mg/1; MEMANTINE HYDROCHLORIDE 14 mg/1Jul 15, 2026Jul 15, 2026
Vitruvias Therapeutics, Inc.DONEPEZIL HYDROCHLORIDE 10 mg/1; MEMANTINE HYDROCHLORIDE 28 mg/1Jul 15, 2026Jul 15, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "memantine hydrochloride and donepezil hydrochloride — NDC 69680-0183-30," retrieved September 3, 2026, https://drugdashboards.com/drug/69680018330.

Free to cite with attribution — see how the data is put together.