The short version
Just 2 companies supply this market — thin enough that a single exit would be felt immediately.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Buscapina
Acetaminophen, Caffeine, Pyrilamine maleate · PYRILAMINE MALEATE 15 mg/1; ACETAMINOPHEN 500 mg/1; CAFFEINE 60 mg/1 · Tablet, Coated · Oral · Opmx Llc
NDC 69729-0818-50 · 50 POUCH in 1 CARTON / 2 TABLET, COATED in 1 POUCH · OTC MONOGRAPH DRUG · View full market →
Medicare Part D
Medicare Part D does not cover over-the-counter drugs — by law it pays only for products requiring a prescription.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
Is this a "specialty" drug?
There's no legal definition — it meets 1 of 6 public criteria. Why that matters →
- Part D specialty tier
- Costs ≥ $950/fill
- Biologic (BLA)
- Injectable / infused
- Orphan-drug exclusivity
- REMS program · Opioid Analgesic REMS Shared System REMS
Regulatory
- Application
- M013
- TE code
- —
- Approval date
- —
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of Acetaminophen, Caffeine, Pyrilamine maleate (Tablet, Coated)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Pharmadel LLC | ACETAMINOPHEN 500 mg/1; CAFFEINE 60 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Opmx Llc | PYRILAMINE MALEATE 15 mg/1; ACETAMINOPHEN 500 mg/1; CAFFEINE 60 mg/1 | Aug 26, 2026 | Aug 31, 2026 |
| Opmx Llc | ACETAMINOPHEN 500 mg/1; CAFFEINE 60 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Aug 28, 2026 |
| Opmx Llc | PYRILAMINE MALEATE 500 mg/1; ACETAMINOPHEN 60 mg/1; CAFFEINE 15 mg/1 | Jul 22, 2026 | Aug 20, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "Buscapina — NDC 69729-0818-50," retrieved September 3, 2026, https://drugdashboards.com/drug/69729081850.
Free to cite with attribution — see how the data is put together.