DrugDashboards

Sleep-Aid Diphenhydramine HCl

Diphenhydramine Hydrochloride · DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1 · Capsule, Liquid Filled · Oral · Cardinal Health 110, LLC. DBA Leader

NDC 70000-0584-01 · 1 BLISTER PACK in 1 CARTON / 12 CAPSULE, LIQUID FILLED in 1 BLISTER PACK · OTC MONOGRAPH DRUG · View full market →

The short version

33 companies supply this market — deep enough that no single failure threatens the supply. The price is up 13% over the past year, to $0.2208 per unit. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

Medicare Part D

Medicare Part D does not cover over-the-counter drugs — by law it pays only for products requiring a prescription.

How Part D pricing works →

NADAC price per unit

$0$0.1$0.2$0.3Apr 2024Sep 2026$0.2208
29 price points · per EASource: CMS NADAC

Estimated fill cost

#30 count
$6.62
#90 count
$19.87

Estimates: latest NADAC unit price × quantity. Pharmacy acquisition cost only — excludes dispensing fees, markup, and insurance terms.

Medicaid spend (2025)

$484
31 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

0Low risk

Nothing here is signaling trouble: several manufacturers, no current shortage, no recent serious recalls, stable pricing. In drug supply, boring is the good outcome.

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for diphenhydramine hydrochloride (oral solid) in the next 90 days

sole-source market · price up 4% YoY

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Regulatory

Application
M010
TE code
Approval date
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Diphenhydramine Hydrochloride (Capsule, Liquid Filled)

LabelerStrengthFirst seenLast seen
Aenova Romania S.r.lDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 3, 2026
Best Choice (Valu Merchandisers Company)DIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 3, 2026
Cardinal Health 110, LLC. DBA LeaderDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 3, 2026
Cvs Pharmacy, IncDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 3, 2026
Humanwell PuraCap Pharmaceutical (Wuhan), Ltd.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 3, 2026
HyVee IncDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Sep 3, 2026Sep 3, 2026
Pioneer Life Sciences, LlcDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 3, 2026
Softgel Healthcare Private LimitedDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 3, 2026
Softgel Healthcare Pvt LtdDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 3, 2026
Strive Pharmaceuticals Inc.DIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 3, 2026
Walgreen CompanyDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 3, 2026
AmerisourceBergen Drug CorpDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Bioventure Healthcare - FZEDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
BJWC (Berkley & Jensen / BJ's)DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Catalent Ontario LimitedDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Catalent Ontario LimitedDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Catalent Pharma Solutions, LLCDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Chain Drug Marketing AssociationDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Chain Drug Marketing Association, Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Company name: Topco Associates, LLCDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Discount Drug Mart, IncDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Foodhold U.s.a., LlcDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Harris TeeterDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
HebDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Kenvue Brands LLCDIPHENHYDRAMINE HCL 50 mg/1Jul 15, 2026Sep 2, 2026
Kenvue Brands LLCDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Lil' Drug Store Products, Inc.DIPHENHYDRAMINE HYDROCHLORIDE 50 mg/21Jul 15, 2026Sep 2, 2026
Meijer, Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Nuvicare LlcDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Nuvicare LlcDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Pioneer Life Sciences, LLCDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Prodose, Inc.DIPHENHYDRAMINE HYDROCHLORIDE 50 kg/1Jul 15, 2026Sep 2, 2026
Prodose, Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Rising Pharma Holdings, Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Rising Pharma Holdings, Inc.DIPHENHYDRAMINE 50 mg/1Jul 15, 2026Sep 2, 2026
Shield Pharmaceuticals CorpDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Softgel Healthcare Private LimitedDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026
Strive Pharmaceuticals Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
The Kroger CoDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/1Jul 15, 2026Sep 2, 2026
Topco Associates LLCDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/1Jul 15, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Sleep-Aid Diphenhydramine HCl — NDC 70000-0584-01," retrieved September 3, 2026, https://drugdashboards.com/drug/70000058401.

Free to cite with attribution — see how the data is put together.