The short version
Only one company currently supplies this market — there is no backup if it stumbles.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Amvuttra
Vutrisiran · VUTRISIRAN SODIUM 25 mg/.5mL · Injection · Subcutaneous · Alnylam Pharmaceuticals, Inc.
NDC 71336-1003-01 · 1 SYRINGE, GLASS in 1 CARTON / .5 mL in 1 SYRINGE, GLASS · NDA · View full market →
One drug, every price
The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.
ⓘ How this was built
Data sources
- CMS NADAC (pharmacy acquisition, weekly)
- CMS Part B ASP quarterly payment limits
- CMS Maximum Fair Prices (IRA negotiated, NDC-level)
- Medicare Part D Spending by Drug (data.cms.gov, name-matched)
- VA FSS / Big4 federal contract prices (va.gov, twice monthly)
- ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
- California SB-17 WAC filings (list price, per package)
Method
Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
- Medicare Part B pays (ASP+6%)$5,012.60per billing unit (1 MG)HCPCS J0225 · Jul 1, 2026
- Part D plans paid (avg)$236,450.75per dosage unitgross, before rebates — matched by drug name · 2024
Medicare Part D
No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Estimated fill cost
WAC per package, as filed
$119,351.00
Reported to Texas DSHS · 2026 annual filing · Alnylam Pharmaceuticals
Manufacturer list price as filed — not what pharmacies actually pay after discounts.
Medicare Part B (ASP)
Payment limit per 1 MG
$5012.599
HCPCS J0225 · Jul 1, 2026 quarter · typically ASP + 6%
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
Is this a "specialty" drug?
There's no legal definition — it meets 3 of 6 public criteria. Why that matters →
- Part D specialty tier
- Costs ≥ $950/fill · avg $118,225.37 per prescription
- Biologic (BLA)
- Injectable / infused
- Orphan-drug exclusivity
- REMS program
Regulatory
- Application
- NDA215515
- TE code
- —
- Approval date
- Jun 13, 2022
- Patents / exclusivity
- 13 patents, 4 exclusivities
| Type | Number / code | Expires |
|---|---|---|
| exclusivity | ODE-527 | Mar 20, 2032 |
| exclusivity | ODE-212 | Jun 13, 2029 |
| exclusivity | I-964 | Mar 20, 2028 |
| exclusivity | NCE | Jun 13, 2027 |
| patent | 11286486 | Jul 28, 2036 |
| patent | 10683501 | Jul 28, 2036 |
| patent | 10208307 | Jul 28, 2036 |
| patent | 12049628 | Jul 28, 2036 |
| patent | 10612024 | Aug 14, 2035 |
| patent | 11401517 | Aug 14, 2035 |
| patent | 9399775 | Nov 16, 2032 |
| patent | 10570391 | Nov 16, 2032 |
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of Vutrisiran (Injection)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Alnylam Pharmaceuticals, Inc. | VUTRISIRAN SODIUM 25 mg/.5mL | Jul 15, 2026 | Sep 2, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "Amvuttra — NDC 71336-1003-01," retrieved September 3, 2026, https://drugdashboards.com/drug/71336100301.
Free to cite with attribution — see how the data is put together.