The short version
Just 3 companies supply this market — thin enough that a single exit would be felt immediately.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Acetaminophen and Ibuprofen (NSAID)
Acetaminophen and Ibuprofen (NSAID) · IBUPROFEN 125 mg/1; ACETAMINOPHEN 250 mg/1 · Tablet · Oral · Retail Business Services,llc
NDC 72476-0131-72 · 72 TABLET in 1 BOTTLE · ANDA · View full market →
Medicare Part D
No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
90-day shortage risk (model v2)
0.1%chance of a new FDA shortage posting for acetaminophen and ibuprofen (oral solid) in the next 90 days
price up 19% YoY · sole-source market
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
Is this a "specialty" drug?
There's no legal definition — it meets 1 of 6 public criteria. Why that matters →
- Part D specialty tier
- Costs ≥ $950/fill
- Biologic (BLA)
- Injectable / infused
- Orphan-drug exclusivity
- REMS program · Opioid Analgesic REMS Shared System REMS
Regulatory
- Application
- ANDA216592
- TE code
- —
- Approval date
- Jul 13, 2023
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of Acetaminophen and Ibuprofen (NSAID) (Tablet)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Retail Business Services,llc | IBUPROFEN 125 mg/1; ACETAMINOPHEN 250 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Rite Aid | IBUPROFEN 125 mg/1; ACETAMINOPHEN 250 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Wal-Mart Stores Inc. | IBUPROFEN 125 mg/1; ACETAMINOPHEN 250 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Retail Business Services,llc | IBUPROFEN 250 mg/1; ACETAMINOPHEN 125 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Rite Aid | IBUPROFEN 250 mg/1; ACETAMINOPHEN 125 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Wal-Mart Stores Inc. | IBUPROFEN 250 mg/1; ACETAMINOPHEN 125 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Retail Business Services,llc | ACETAMINOPHEN 250 mg/1; IBUPROFEN 125 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Rite Aid | ACETAMINOPHEN 250 mg/1; IBUPROFEN 125 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Wal-Mart Stores Inc. | ACETAMINOPHEN 250 mg/1; IBUPROFEN 125 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "Acetaminophen and Ibuprofen (NSAID) — NDC 72476-0131-72," retrieved September 3, 2026, https://drugdashboards.com/drug/72476013172.
Free to cite with attribution — see how the data is put together.