The short version
12 companies supply this market — deep enough that no single failure threatens the supply.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Topcare NiteTime Cold and Flu Relief
acetaminophen, dextromethorphan hydrobromide, doxylamine succinate · ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL · Solution · Oral · Topco Associates LLC
NDC 76162-0599-40 · 355 mL in 1 BOTTLE · OTC MONOGRAPH DRUG · View full market →
Medicare Part D
Medicare Part D does not cover over-the-counter drugs — by law it pays only for products requiring a prescription.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
90-day shortage risk (model v2)
0.1%chance of a new FDA shortage posting for acetaminophen, dextromethorphan hydrobromide, doxylamine succinate (other) in the next 90 days
sole-source market · price up 3% YoY
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
Is this a "specialty" drug?
There's no legal definition — it meets 1 of 6 public criteria. Why that matters →
- Part D specialty tier
- Costs ≥ $950/fill
- Biologic (BLA)
- Injectable / infused
- Orphan-drug exclusivity
- REMS program · Opioid Analgesic REMS Shared System REMS
Regulatory
- Application
- M012
- TE code
- —
- Approval date
- —
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of acetaminophen, dextromethorphan hydrobromide, doxylamine succinate (Solution)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Amazon.com Services LLC | ACETAMINOPHEN 650 mg/30mL; DEXTROMETHORPHAN HYDROBROMIDE 30 mg/30mL; DOXYLAMINE SUCCINATE 12.5 mg/30mL | Jul 15, 2026 | Sep 3, 2026 |
| Cvs Woonsocket Prescription Center, Incorporated | ACETAMINOPHEN 650 mg/30mL; DEXTROMETHORPHAN HYDROBROMIDE 30 mg/30mL; DOXYLAMINE SUCCINATE 12.5 mg/30mL | Jul 15, 2026 | Sep 3, 2026 |
| L Perrigo Company | ACETAMINOPHEN 650 mg/30mL; DEXTROMETHORPHAN HYDROBROMIDE 20 mg/30mL; DOXYLAMINE SUCCINATE 12.5 mg/30mL | Jul 15, 2026 | Sep 3, 2026 |
| L. Perrigo Company | ACETAMINOPHEN 650 mg/30mL; DEXTROMETHORPHAN HYDROBROMIDE 30 mg/30mL; DOXYLAMINE SUCCINATE 12.5 mg/30mL | Jul 15, 2026 | Sep 3, 2026 |
| Wal-Mart Stores Inc | ACETAMINOPHEN 650 mg/30mL; DEXTROMETHORPHAN HYDROBROMIDE 30 mg/30mL; DOXYLAMINE SUCCINATE 12.5 mg/30mL | Jul 15, 2026 | Sep 3, 2026 |
| Dolgencorp Inc | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
| HyVee Inc | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
| L. Perrigo Company | ACETAMINOPHEN 650 mg/30mL; DEXTROMETHORPHAN HYDROBROMIDE 30 mg/30mL; DOXYLAMINE SUCCINATE 12.6 mg/30mL | Jul 15, 2026 | Sep 2, 2026 |
| L. Perrigo Company | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
| Meijer, Inc. | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
| Meijer, Inc. | ACETAMINOPHEN 1000 mg/30mL; DEXTROMETHORPHAN HYDROBROMIDE 30 mg/30mL; DOXYLAMINE SUCCINATE 12.5 mg/30mL | Jul 15, 2026 | Sep 2, 2026 |
| Safeway | ACETAMINOPHEN 650 mg/30mL; DEXTROMETHORPHAN HYDROBROMIDE 30 mg/30mL; DOXYLAMINE SUCCINATE 12.5 mg/30mL | Jul 15, 2026 | Sep 2, 2026 |
| Sportpharm LLC | ACETAMINOPHEN 650 mg/30mL; DEXTROMETHORPHAN HYDROBROMIDE 30 mg/30mL; DOXYLAMINE SUCCINATE 12.5 mg/30mL | Jul 15, 2026 | Sep 2, 2026 |
| Strategic Sourcing Services LLC | ACETAMINOPHEN 650 mg/30mL; DEXTROMETHORPHAN HYDROBROMIDE 30 mg/30mL; DOXYLAMINE SUCCINATE 12.5 mg/30mL | Jul 15, 2026 | Sep 2, 2026 |
| Topco Associates LLC | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "Topcare NiteTime Cold and Flu Relief — NDC 76162-0599-40," retrieved September 3, 2026, https://drugdashboards.com/drug/76162059940.
Free to cite with attribution — see how the data is put together.