The short version
15 companies supply this market — deep enough that no single failure threatens the supply.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
night time cold and flu
acetaminophen, dextromethorphan hydrobromide, doxylamine succinate, phenylephrine hydrochloride · ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/15mL · Solution · Oral · Meijer, Inc.
NDC 79481-8999-00 · 355 mL in 1 BOTTLE · OTC MONOGRAPH DRUG · View full market →
Medicare Part D
Medicare Part D does not cover over-the-counter drugs — by law it pays only for products requiring a prescription.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
90-day shortage risk (model v2)
0.1%chance of a new FDA shortage posting for acetaminophen, dextromethorphan hydrobromide, doxylamine succinate, phenylephrine hydrochloride (other) in the next 90 days
sole-source market
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
Is this a "specialty" drug?
There's no legal definition — it meets 1 of 6 public criteria. Why that matters →
- Part D specialty tier
- Costs ≥ $950/fill
- Biologic (BLA)
- Injectable / infused
- Orphan-drug exclusivity
- REMS program · Opioid Analgesic REMS Shared System REMS
Regulatory
- Application
- M012
- TE code
- —
- Approval date
- —
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of acetaminophen, dextromethorphan hydrobromide, doxylamine succinate, phenylephrine hydrochloride (Solution)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Amazon.com Services LLC | ACETAMINOPHEN 650 mg/30mL; DEXTROMETHORPHAN HYDROBROMIDE 20 mg/30mL; DOXYLAMINE SUCCINATE 12.5 mg/30mL; PHENYLEPHRINE HYDROCHLORIDE 10 mg/30mL | Jul 15, 2026 | Sep 3, 2026 |
| L. Perrigo Company | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/15mL | Jul 15, 2026 | Sep 3, 2026 |
| Amazon.com Services LLC | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
| Dolgencorp Inc | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
| H E B | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
| HyVee Inc | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
| L Perrigo Company | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
| L Perrigo Company | ACETAMINOPHEN 650 mg/30mL; DEXTROMETHORPHAN HYDROBROMIDE 20 mg/30mL; DOXYLAMINE SUCCINATE 12.5 mg/30mL; PHENYLEPHRINE HYDROCHLORIDE 10 mg/30mL | Jul 15, 2026 | Sep 2, 2026 |
| L. Perrigo Company | ACETAMINOPHEN 650 mg/30mL; DEXTROMETHORPHAN HYDROBROMIDE 20 mg/30mL; DOXYLAMINE SUCCINATE 12.5 mg/30mL; PHENYLEPHRINE HYDROCHLORIDE 10 mg/30mL | Jul 15, 2026 | Sep 2, 2026 |
| Meijer, Inc. | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
| Publix Super Markets Inc | ACETAMINOPHEN 650 mg/30mL; DEXTROMETHORPHAN HYDROBROMIDE 20 mg/30mL; DOXYLAMINE SUCCINATE 12.5 mg/30mL; PHENYLEPHRINE HYDROCHLORIDE 10 mg/30mL | Jul 15, 2026 | Sep 2, 2026 |
| Rite Aid Corporation | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
| Strategic Sourcing Services LLC | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
| Topco Associates LLC | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
| Wal-Mart Stores Inc | ACETAMINOPHEN 650 mg/30mL; DEXTROMETHORPHAN HYDROBROMIDE 20 mg/30mL; DOXYLAMINE SUCCINATE 12.5 mg/30mL; PHENYLEPHRINE HYDROCHLORIDE 10 mg/30mL | Jul 15, 2026 | Sep 2, 2026 |
| Walgreen Company | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
| Walmart Inc. | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/15mL | Jul 15, 2026 | Sep 2, 2026 |
| Cvs Woonsocket Prescription Center, Incorporated | ACETAMINOPHEN 325 mg/15mL; DEXTROMETHORPHAN HYDROBROMIDE 10 mg/15mL; DOXYLAMINE SUCCINATE 6.25 mg/15mL; PHENYLEPHRINE HYDROCHLORIDE 5 mg/15mL | Jul 15, 2026 | Aug 31, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "night time cold and flu — NDC 79481-8999-00," retrieved September 3, 2026, https://drugdashboards.com/drug/79481899900.
Free to cite with attribution — see how the data is put together.