The short version
14 companies supply this market — deep enough that no single failure threatens the supply.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Butalbital, Acetaminophen And Caffeine
Butalbital, Acetaminophen And Caffeine · BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 · Tablet · Oral · Advanced Rx of Tennessee, LLC
NDC 80425-0567-01 · 30 TABLET in 1 BOTTLE, PLASTIC · ANDA · View full market →
Medicare Part D
No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
90-day shortage risk (model v2)
0.1%chance of a new FDA shortage posting for butalbital, acetaminophen and caffeine (oral solid) in the next 90 days
OAI inspection at a producing facility (24 months) · sole-source market
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
Where it's made
- Advanced Rx Pharmacy of Tennessee, LLCUnited Statesrepack
Establishments this product's FDA label declares, located via FDA registration data. How we built this →
Is this a "specialty" drug?
There's no legal definition — it meets 1 of 6 public criteria. Why that matters →
- Part D specialty tier
- Costs ≥ $950/fill
- Biologic (BLA)
- Injectable / infused
- Orphan-drug exclusivity
- REMS program · Opioid Analgesic REMS Shared System REMS
Regulatory
- Application
- ANDA214287
- TE code
- AA
- Approval date
- Jan 18, 2024
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of Butalbital, Acetaminophen And Caffeine (Tablet)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Bryant Ranch Prepack | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| Preferred Pharmaceuticals Inc. | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| A-S Medication Solutions | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Advanced Rx of Tennessee, LLC | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Chartwell RX, LLC | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Golden State Medical Supply, Inc. | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| KVK-Tech, Inc. | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Mikart, LLC | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Proficient Rx LP | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Quagen Pharmaceuticals Llc | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Redpharm Drug | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Remedyrepack Inc. | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| St. Mary's Medical Park Pharmacy | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Granules Pharmaceuticals Inc. | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 20, 2026 | Aug 31, 2026 |
| Granules Pharmaceuticals Inc. | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 25, 2026 |
| Bryant Ranch Prepack | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 22, 2026 |
| Preferred Pharmaceuticals Inc. | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 20, 2026 |
| A-S Medication Solutions | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Advanced Rx of Tennessee, LLC | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Chartwell RX, LLC | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Golden State Medical Supply, Inc. | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| KVK-Tech, Inc. | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Mikart, LLC | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Proficient Rx LP | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Quagen Pharmaceuticals Llc | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Redpharm Drug | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Remedyrepack Inc. | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| St. Mary's Medical Park Pharmacy | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Preferred Pharmaceuticals Inc. | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 19, 2026 |
| Bryant Ranch Prepack | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 18, 2026 |
| Granules Pharmaceuticals Inc. | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 16, 2026 |
| A-S Medication Solutions | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Advanced Rx of Tennessee, LLC | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Chartwell RX, LLC | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Golden State Medical Supply, Inc. | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| KVK-Tech, Inc. | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Mikart, LLC | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Proficient Rx LP | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Quagen Pharmaceuticals Llc | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Redpharm Drug | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "Butalbital, Acetaminophen And Caffeine — NDC 80425-0567-01," retrieved September 3, 2026, https://drugdashboards.com/drug/80425056701.
Free to cite with attribution — see how the data is put together.