DrugDashboards

Piperacillin and Tazobactam

Piperacillin sodium and Tazobactam sodium · PIPERACILLIN SODIUM 36 g/180mL; TAZOBACTAM SODIUM 4.5 g/180mL · Injection, Powder, Lyophilized, For Solution · Intravenous · Provepharm Inc.

NDC 81284-0155-01 · 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON / 180 mL in 1 VIAL, PHARMACY BULK PACKAGE · ANDA · View full market →

The short version

Just 3 companies supply this market — thin enough that a single exit would be felt immediately. Historically, drugs in this position went on to a new shortage within 90 days about 0.5% of the time — roughly 4× the typical drug (0.1%).

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Medicare Part B pays (ASP+6%)$1.22per billing unit (1.125 GM)HCPCS J2543 · Jul 1, 2026
  • Federal contracts pay (FSS)$68.00per unitAvKare, LLC · Jun 15, 2023

Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.

Estimated fill cost

WAC per package, as filed
$69.00
Reported to Texas DSHS · 2026 annual filing · Provepharm, Inc.

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicare Part B (ASP)

Payment limit per 1.125 GM
$1.218
HCPCS J2543 · Jul 1, 2026 quarter · typically ASP + 6%

Medicaid spend (2025)

$50,185
923 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

Not scored — fragility is computed for NADAC-priced NDCs.

90-day shortage risk (model v2)

0.5%chance of a new FDA shortage posting for piperacillin sodium and tazobactam sodium (injectable) in the next 90 days

sterile injectable · OAI inspection at a producing facility (24 months) · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is 4× that.

Backtested statistical model over the whole market, not this package alone. Model details →

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

  • Part D specialty tier
  • Costs ≥ $950/fill
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program

Regulatory

Application
ANDA207848
TE code
AP
Approval date
Jan 13, 2017
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Piperacillin sodium and Tazobactam sodium (Injection, Powder, Lyophilized, For Solution)

LabelerStrengthFirst seenLast seen
Eugia US LLCPIPERACILLIN SODIUM 4 g/1; TAZOBACTAM SODIUM .5 g/1Jul 15, 2026Sep 3, 2026
Eugia US LLCPIPERACILLIN SODIUM 2 g/1; TAZOBACTAM SODIUM .25 g/1Jul 15, 2026Sep 3, 2026
Eugia US LLCPIPERACILLIN SODIUM 36 g/250mL; TAZOBACTAM SODIUM 4.5 g/250mLJul 15, 2026Sep 2, 2026
Eugia US LLCPIPERACILLIN SODIUM 12 g/100mL; TAZOBACTAM SODIUM 1.5 g/100mLJul 15, 2026Sep 2, 2026
Mitim S.r.l.PIPERACILLIN SODIUM 3 g/15mL; TAZOBACTAM SODIUM .375 g/15mLJul 15, 2026Sep 2, 2026
Mitim S.r.l.PIPERACILLIN SODIUM 4 g/20mL; TAZOBACTAM SODIUM .5 g/20mLJul 15, 2026Sep 2, 2026
Mitim S.r.l.PIPERACILLIN SODIUM 2 g/10mL; TAZOBACTAM SODIUM .25 g/10mLJul 15, 2026Sep 2, 2026
Provepharm Inc.PIPERACILLIN SODIUM 4 g/20mL; TAZOBACTAM SODIUM .5 g/20mLJul 15, 2026Sep 2, 2026
Provepharm Inc.PIPERACILLIN SODIUM 12 g/60mL; TAZOBACTAM SODIUM 1.5 g/60mLJul 15, 2026Sep 2, 2026
Provepharm Inc.PIPERACILLIN SODIUM 2 g/10mL; TAZOBACTAM SODIUM .25 g/10mLJul 15, 2026Sep 2, 2026
Provepharm Inc.PIPERACILLIN SODIUM 3 g/15mL; TAZOBACTAM SODIUM .375 g/15mLJul 15, 2026Sep 2, 2026
Provepharm Inc.PIPERACILLIN SODIUM 36 g/180mL; TAZOBACTAM SODIUM 4.5 g/180mLJul 15, 2026Sep 2, 2026
Eugia US LLCPIPERACILLIN SODIUM 3 g/1; TAZOBACTAM SODIUM .375 g/1Jul 15, 2026Aug 31, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Piperacillin and Tazobactam — NDC 81284-0155-01," retrieved September 3, 2026, https://drugdashboards.com/drug/81284015501.

Free to cite with attribution — see how the data is put together.